Indian heart journal · 2019
QT prolongation in HIV-positive patients: Review article.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Liu Jing, Shah Sumit K, Basu-Ray Indranill, Garcia-Diaz Julia, Khalid Kainat, Saeed Mohammad
Аннотация
INTRODUCTION: Antiretrovirals have immensely increased the average life expectancy of HIV-positive patients. However, the incidence of QT interval prolongation and other arrhythmias has also increased.
METHODS: Pubmed and Google Scholar were searched for relevant literature published between 1990 and 2019.
RESULTS AND DISCUSSION: HIV-positive patients with high viral load, low CD4 count, chronic inflammation, and autonomic neuropathy can develop QT interval prolongation. Another factor prolonging QT interval includes exposure to the HIV transactivator protein, which inhibits hERG K (+) channels controlling IKr K (+) currents in cardiomyocytes. Protease inhibitors inhibiting the CYP3A4 enzyme can also lead to QT interval prolongation. QT interval prolongation can potentially be exacerbated by opioids, antipsychotics, antibiotics, and antifungals, the adjunct medications often used in HIV-positive patients. Hepatic insufficiency in seropositive patients on antiretrovirals may also increase the risk of QT interval prolongation.
CONCLUSION: Baseline and follow-up EKG in the susceptible population is suggested.
METHODS: Pubmed and Google Scholar were searched for relevant literature published between 1990 and 2019.
RESULTS AND DISCUSSION: HIV-positive patients with high viral load, low CD4 count, chronic inflammation, and autonomic neuropathy can develop QT interval prolongation. Another factor prolonging QT interval includes exposure to the HIV transactivator protein, which inhibits hERG K (+) channels controlling IKr K (+) currents in cardiomyocytes. Protease inhibitors inhibiting the CYP3A4 enzyme can also lead to QT interval prolongation. QT interval prolongation can potentially be exacerbated by opioids, antipsychotics, antibiotics, and antifungals, the adjunct medications often used in HIV-positive patients. Hepatic insufficiency in seropositive patients on antiretrovirals may also increase the risk of QT interval prolongation.
CONCLUSION: Baseline and follow-up EKG in the susceptible population is suggested.
Предметные рубрики MeSH
Analgesics, OpioidAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveArrhythmias, CardiacAutonomic Nervous System DiseasesCD4 Lymphocyte CountElectrocardiographyHIV InfectionsHIV Protease InhibitorsHepatitis B, ChronicHepatitis C, ChronicHumansInflammationMethadoneOpiate Substitution TreatmentViral Load