European journal of obstetrics, gynecology, and reproductive biology · 2018
Placental pathology and neonatal outcome in small for gestational age pregnancies with and without abnormal umbilical artery Doppler flow.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ganer Herman Hadas, Barber Elad, Gasnier Rose, Gindes Liat, Bar Jacob, Schreiber Letizia, Kovo Michal
Аннотация
OBJECTIVE: To compare neonatal outcome and placental pathology in cases of small for gestational age (SGA) according to umbilical artery (UA) Doppler flow.
STUDY DESIGN: Pregnancy and placental reports of SGA neonates (birth-weight <10th), born between 2008 and 2017 were compared between cases with normal and abnormal UA Doppler indices. Placental lesions were classified to malperfusion lesions and inflammatory responses.
RESULTS: The abnormal Doppler group (n = 66) delivered at an earlier gestational age, compared to the normal Doppler group (n = 92). Placentas from the abnormal Doppler group were characterized by a higher rate of maternal malperfusion lesions, while placentas from the normal Doppler group exhibited a higher rate of chronic villitis. Neonatal outcome was independently associated with abnormal Doppler, gestational age and birth weight <5th percentile.
CONCLUSION: SGA may involve a vascular mechanism, associated with abnormal Doppler flow and placental malperfusion, and an inflammatory mechanism, with normal Doppler flow and chronic villitis.
STUDY DESIGN: Pregnancy and placental reports of SGA neonates (birth-weight <10th), born between 2008 and 2017 were compared between cases with normal and abnormal UA Doppler indices. Placental lesions were classified to malperfusion lesions and inflammatory responses.
RESULTS: The abnormal Doppler group (n = 66) delivered at an earlier gestational age, compared to the normal Doppler group (n = 92). Placentas from the abnormal Doppler group were characterized by a higher rate of maternal malperfusion lesions, while placentas from the normal Doppler group exhibited a higher rate of chronic villitis. Neonatal outcome was independently associated with abnormal Doppler, gestational age and birth weight <5th percentile.
CONCLUSION: SGA may involve a vascular mechanism, associated with abnormal Doppler flow and placental malperfusion, and an inflammatory mechanism, with normal Doppler flow and chronic villitis.
Предметные рубрики MeSH
AdultFemaleFetal Growth RetardationHumansHypertension, Pregnancy-InducedInfant, NewbornInfant, Small for Gestational AgeIsraelMalePlacentaPlacenta DiseasesPlacental CirculationPre-EclampsiaPregnancyPregnancy Complications, CardiovascularPrevalenceRetrospective StudiesUltrasonography, Doppler, ColorUltrasonography, Doppler, PulsedUltrasonography, PrenatalUmbilical ArteriesYoung Adult