Clinical biochemistry · 2014
Hook effect in Abbott i-STAT β-human chorionic gonadotropin (β-hCG) point of care assay.
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Wilgen Urs, Pretorius Carel J, Gous Rehna S, Martin Cameron, Hale Vincent J, Ungerer Jacobus P J
Аннотация
UNLABELLED: Point-of-care testing for β-hCG has been widely advocated to allow rapid diagnosis/exclusion of pregnancy in the emergency department. A quantitative blood β-hCG assay has the additional benefit of being able to monitor the viability of pregnancy, using serial measurements, to determine the appropriate expected increase in β-hCG levels over time (e.g. ectopic pregnancy), and aiding in determining if an intrauterine gestational sac should be visible on sonographic imaging.
OBJECTIVES: Evaluation of the newly released Abbott i-STAT β-hCG point-of-care assay with the Beckman Coulter β-hCG laboratory assay in use.
DESIGN AND METHODS: Whole blood, plasma and serum samples with a wide range of β-hCG concentrations were analysed by both methods.
RESULTS: The Abbott I-STAT β-hCG compares favourably, can be performed on heparinised whole blood, plasma and serum, and shows acceptable accuracy and precision. However a hook effect at elevated β-hCG was shown in gestational trophoblastic disease as well as normal pregnancies.
CONCLUSIONS: The i-STAT β-hCG performs acceptably in its intended use in the early detection of pregnancy, but results should always be interpreted within the clinical context, as a hook effect may occur.
OBJECTIVES: Evaluation of the newly released Abbott i-STAT β-hCG point-of-care assay with the Beckman Coulter β-hCG laboratory assay in use.
DESIGN AND METHODS: Whole blood, plasma and serum samples with a wide range of β-hCG concentrations were analysed by both methods.
RESULTS: The Abbott I-STAT β-hCG compares favourably, can be performed on heparinised whole blood, plasma and serum, and shows acceptable accuracy and precision. However a hook effect at elevated β-hCG was shown in gestational trophoblastic disease as well as normal pregnancies.
CONCLUSIONS: The i-STAT β-hCG performs acceptably in its intended use in the early detection of pregnancy, but results should always be interpreted within the clinical context, as a hook effect may occur.