Design of new sensing layer based on ZnO/NiO/Fe3O4/MWCNTs nanocomposite for simultaneous electrochemical determination of Naproxen and Sumatriptan.

Naproxen sodium (NAP) and Sumatriptan (SUM) are pharmacological migraine therapies that are more efficient when administered in combination. In the present work, an electrochemical sensor was developed for simultaneous and sensitive NAP and SUM detection using MWCNTs decorated with ZnO, NiO and Fe3O4 nanoparticles on glassy carbon electrode (GCE). This report is the first research on simultaneous electrochemical measuring the target drugs based on the literature. The data show that modification of the GCE surface with ZnO/NiO/Fe3O4/MWCNTs nanocomposite remarkably improves the electro-oxidation peaks currents but the peaks potential of NAP and SUM have shifted to the lower potential which demonstrates that electro-oxidation of target drugs have done more easier than GCE at the surface of modified electrode. The nanocomposite was recognized by using Fourier transform infrared spectroscopy (FTIR) and field emission scanning electron microscopy (FE-SEM), and X-ray diffraction (XRD). The improved electrode was estimated by various methods, including cyclic voltammetry (CV), square wave voltammetry (SWV), and electrochemical impedance spectroscopy (EIS) techniques. Influencing parameters containing the supporting electrolytes, pH, scan rate, deposition potential, and accumulation time were optimized. The linear detection ranges were from 4.00 nMto 350.00 μM for NAP and from 6.00 nM to 380.00 μM for SUM, with the detection limits of 3.00 nMfor NAP and 2.00 nM for SUM, respectively. The repeatability, linearity, and selectivity of ZnO/NiO/Fe3O4/MWCNTs/GCE were investigated, and the received outcomes divulged the efficiency of the electrode. The consequence of high-performance liquid chromatography (HPLC) and recovery show the method's suitability for the simultaneous determination of NAP and SUM in the biological fluids and pharmaceutical compounds.