Structural Change of Neurotransmitter Amine with CO2 in Water: Formation of Covalently Bound Carbamic Acid.

Structural transformation changes the activity of biological reactions. Neurotransmitter aralkylamines, such as phenethylamine, tyramine, dopamine, tryptamine, serotonin, and histamine, absorb aerial CO2, and heteronuclear multiple bond connectivity (HMBC) correlations between the carbon derived from CO2 and the α-hydrogen of the several amines were confirmed in the D2O solution. The isolation of methyl carbamate from phenethylamine and CO2 in water with TMSCHN2 also supported the formation of covalently bound carbamic acid in the amine aqueous solution containing CO2. Therefore, it is suggested that CO2 produced in the body would react with neurotransmitter amines to form covalently bound carbamic acid, which might affect biological reactions.