Медицинская библиотека · Journal of infection and public health · 2023

Prevalence and factors associated with tuberculosis infection in India.

Selvaraju Sriram, Velayutham Banurekha, Rao Raghuram, Rade Kiran, Thiruvengadam Kannan, Asthana Smita, Balachandar Rakesh, Bangar Sampada Dipak, Bansal Avi Kumar, Bhat Jyothi, Chopra Vishal, Das Dasarathi, Dutta Shantha, Devi Kangjam Rekha, Dwivedi Gaurav Raj, Kalliath Arshad, Laxmaiah Avula, Madhukar Major, Mahapatra Amarendra, Mohanty Suman Sundar, Rangaraju Chethana, Turuk Jyotirmayee, Menon Pradeep Aravindan, Krishnan Rajendran, Singh Manjula, Sekar Krithikaa, Robinson Aby, Turuk Alka, Krishnan Nivethitha N, Srinivasan Nivetha, Rexy Catherine, Suresh M, Hanna Luke Elizabeth, Choudhury Avijit H, Parmar Malik, Ramachandran Ranjani, Kumar Nishant, Joshi Rajendra Panduranga, Narasimhaiah Somashekar, Chandrasekaran Padmapriyadarsini, Khan A M, Panda Samiran, Bhargava Balram, National TB Prevalence Survey Group

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Аннотация

BACKGROUND

The risk of tuberculosis (TB) disease is higher in individuals with TB infection. In a TB endemic country like India, it is essential to understand the current burden of TB infection at the population level. The objective of the present analysis is to estimate the prevalence of TB infection in India and to explore the factors associated with TB infection.

METHODS

Individuals aged > 15 years in the recently completed National TB prevalence survey in India who were tested for TB infection by QuantiFERON-TB Gold Plus (QFT-Plus) assay were considered for this sub-analysis. TB infection was defined as positive by QFT-Plus (value >0.35 IU/ml). The estimates for prevalence, prevalence ratio (PR) and adjusted risk ratio (aRR) estimates with 95% confidence intervals (CIs) were calculated.

RESULTS

Of the 16864 individuals analysed, the prevalence of TB infection was 22.6% (95% CI:19.4 -25.8). Factors more likely to be associated with TB infection include age > 30 years (aRR:1.49;95% CI:1.29-1.73), being male (aRR:1.26; 95%CI: 1.18-1.34), residing in urban location (aRR:1.58; 95%CI: 1.03-2.43) and past history of TB (aRR:1.49; 95%CI: 1.26-1.76).

CONCLUSION

About one fourth (22.6%) of the individuals were infected with TB in India. Individuals aged > 30 years, males, residing in urban location, and those with past history of TB were more likely to have TB infection. Targeted interventions for prevention of TB and close monitoring are essential to reduce the burden of TB in India.

Для цитирования: Selvaraju Sriram, Velayutham Banurekha, Rao Raghuram, Rade Kiran, Thiruvengadam Kannan, Asthana Smita, Balachandar Rakesh, Bangar Sampada Dipak, Bansal Avi Kumar, Bhat Jyothi, Chopra Vishal, Das Dasarathi, Dutta Shantha, Devi Kangjam Rekha, Dwivedi Gaurav Raj, Kalliath Arshad, Laxmaiah Avula, Madhukar Major, Mahapatra Amarendra, Mohanty Suman Sundar, Rangaraju Chethana, Turuk Jyotirmayee, Menon Pradeep Aravindan, Krishnan Rajendran, Singh Manjula, Sekar Krithikaa, Robinson Aby, Turuk Alka, Krishnan Nivethitha N, Srinivasan Nivetha, Rexy Catherine, Suresh M, Hanna Luke Elizabeth, Choudhury Avijit H, Parmar Malik, Ramachandran Ranjani, Kumar Nishant, Joshi Rajendra Panduranga, Narasimhaiah Somashekar, Chandrasekaran Padmapriyadarsini, Khan A M, Panda Samiran, Bhargava Balram, National TB Prevalence Survey Group. Prevalence and factors associated with tuberculosis infection in India.. Journal of infection and public health. 2023. DOI: 10.1016/j.jiph.2023.10.009.

Предметные рубрики MeSH

Humans Male Female Prevalence Tuberculosis Latent Tuberculosis India Interferon-gamma Release Tests Tuberculin Test

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