A Cross-Sectional Comprehensive Assessment of the Profile and Burden of Non-motor Symptoms in Relation to Motor Phenotype in the Nigeria Parkinson Disease Registry Cohort.
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Ojo Oluwadamilola O, Wahab Kolawole W, Bello Abiodun H, Abubakar Sani A, Ekeh Bertha C, Otubogun Folajimi M, Iwuozo Emmanuel U, Farombi Temitope H, Adeniji Olaleye, Ojini Francis I, Imarhiagbe Frank A, Nyandaiti Yakub, Komolafe Morenikeji A, Fawale Michael B, Onwuegbuzie Gerald A, Zubair Yusuf, Williams Uduak E, Taiwo Funlola T, Oyakhire Shyngle I, Oshinaike Olajumoke O, Osemwegie Nosakhare, Osaigbovo Godwin O, Odiase Francis E, Odeniyi Olanike A, Obiabo Yahaya O, Obehighe Emmanuel E, Nwazor Ernest O, Nwani Paul O, Kehinde Abiodun J, Erameh Cyril O, Ekenze Oluchi S, Dike Franklin O, Balarabe Salisu A, Arigbodi Ohwotemu, Arabambi Babawale, Ani-Osheku Ifeyinwa, Ali Mohammed W, Akpekpe John E, Akinyemi Rufus O, Agulanna Uchechi, Agu Christian E, Agabi Osigwe P, Ademiluyi Babatunde A, Adebowale Akintunde A, Achoru Charles O, Abiodun Oladunni V, Rizig Mie, Okubadejo Njideka U
Аннотация
OBJECTIVE: To describe the profile of NMS in the Nigeria PD Registry (NPDR) cohort and explore the relationship between NMS and PD motor phenotype.
METHODS: We conducted a cross-sectional study of the frequency and burden of NMS, based on the non-motor symptoms scale (NMSS) and the Chaudhuri method respectively in our cohort. Baseline demographics, disease characteristics (Hoehn and Yahr stage, MDS-UPDRS total score and Part III motor score), motor phenotype (based on Stebbin et al's algorithm), and levodopa equivalent daily dose (LEDD) were documented.
RESULTS: Data are presented for 825 PD whose mean age at study was 63.7 ± 10.1 years, female sex-221 [26.8%] while median PD duration was 36 months. PD phenotypes included tremor-dominant 466 (56.5%), postural instability and gait disorder (PIGD) 259 (31.4%), and indeterminate 100 (12.1%). 82.6% were on treatment (median LEDD of 500 mg/24 hours). 804 (97.5%) endorsed at least 1 NMS. The median NMSS score was 26.0 while subscores for urinary and sexual function domains were significantly higher in males (P < 0.05). PIGD-PD had more frequent NMS and higher frequency of severe/very severe NMSS burden (P = 0.000 for both). Nocturia and fatigue were the most prevalent NMS overall and across motor subtypes. PIGD phenotype and total UPDRS scores were the independent determinants of NMSS scores (P = 0.000).
CONCLUSION: The profile and burden of NMS, and association with motor subtype in our black African cohort is largely similar to descriptions from other populations.