American journal of veterinary research · 1996
Effects of acepromazine maleate and phenoxybenzamine on urethral pressure profiles of anesthetized, healthy, sexually intact male cats.
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Marks S L, Straeter-Knowlen I M, Moore M, Speth R, Rishniw M, Knowlen G G
Аннотация
OBJECTIVES: To evaluate the effects of 2 compounds with alpha adrenergic antagonist properties on the urethral pressures of anesthetized, healthy, sexually intact male cats, and to evaluate one of the compounds for effect on striated muscle.
ANIMALS: 20 healthy, sexually intact male cats.
PROCEDURE: Cats were anesthetized with halothane, and urethral pressure profilometry was performed before and after treatment. 125I-labeled alpha-bungarotoxin bound to nicotinic receptors of murine skeletal muscle was used in a competitive binding study with acepromazine maleate.
RESULTS: Acepromazine maleate significantly decreased intraurethral pressures in the preprostatic (19%) and prostatic (21%) regions of the urethra. There was no effect on the postprostatic/penile segment. Acepromazine did not inhibit 125I-labeled alpha-bungarotoxin binding to nicotinic receptors in murine skeletal muscle. Phenoxybenzamine significantly decreased intraurethral pressures (14%) in the preprostatic region of the urethra only.
CONCLUSIONS: Acepromazine maleate and phenoxybenzamine have effects on the smooth muscle of the urethra of healthy, male cats. Acepromazine has no effect on striated muscle.
CLINICAL RELEVANCE: alpha-Adrenergic compounds may be used in the pharmacologic management of feline urinary tract disease.
ANIMALS: 20 healthy, sexually intact male cats.
PROCEDURE: Cats were anesthetized with halothane, and urethral pressure profilometry was performed before and after treatment. 125I-labeled alpha-bungarotoxin bound to nicotinic receptors of murine skeletal muscle was used in a competitive binding study with acepromazine maleate.
RESULTS: Acepromazine maleate significantly decreased intraurethral pressures in the preprostatic (19%) and prostatic (21%) regions of the urethra. There was no effect on the postprostatic/penile segment. Acepromazine did not inhibit 125I-labeled alpha-bungarotoxin binding to nicotinic receptors in murine skeletal muscle. Phenoxybenzamine significantly decreased intraurethral pressures (14%) in the preprostatic region of the urethra only.
CONCLUSIONS: Acepromazine maleate and phenoxybenzamine have effects on the smooth muscle of the urethra of healthy, male cats. Acepromazine has no effect on striated muscle.
CLINICAL RELEVANCE: alpha-Adrenergic compounds may be used in the pharmacologic management of feline urinary tract disease.