Prolonged QT interval: a marker of sudden infant death syndrome?

A prospective electrocardiographic study was performed in 1830 newborns to evaluate the predictive value of QT interval for sudden infant death syndrome (SIDS). Standard ECG, with babies asleep, was recorded at the ages of 4 days, 2, 4, 6 months, and 1 year. The QTc (+/- SD) was 392 +/- 22 at 4 days, 410 +/- 16 (p less than 0.0001) at 2 months (n = 1256), 404 +/- 16 at 4 months (n = 1015), 400 +/- 16 at 6 months (n = 895), and 398 +/- 15 at 1 year (n = 890). QTc values longer than the mean plus 3 standard deviations were considered prolonged. Heart rate values (beats/min) were 138 +/- 19 at 4 days, 141 +/- 13 at 2 months, 134 +/- 13 at 4 months, 133 +/- 13 at 6 months, and 128 +/- 14 at 1 year. In 34 babies the QT interval was prolonged (mean + 3SD) and 3 of these died suddenly: the first, at 3 months (QTc = 470 and HR = 147 at 4 days); the second after 7 weeks (QTc = 514, HR = 115); the third at 3 months (QTc = 464 and HR = 140 at 4 days).