Медицинская библиотека · Disease markers · 2015

Circulating soluble neuropilin-1 in patients with early cervical cancer and cervical intraepithelial neoplasia can be used as a valuable diagnostic biomarker.

Yang Shouhua, Cheng Henghui, Huang Zaiju, Wang Xiaoling, Wan Yinglu, Cai Jing, Wang Zehua

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

OBJECTIVE

To investigate soluble neuropilin-1 (sNRP-1) in circulating and NRP-1 protein in cervical tissues from patients with cervical cancer or cervical intraepithelial neoplasia (CIN).

METHODS

sNRP-1 was measured in 64 preoperative patients and 20 controls. NRP-1 protein in cervical tissue was detected in 56 patients and 20 controls.

RESULTS

Both sNRP-1 and NRP-1 proteins were correlated with stage. sNRP-1 presented a high diagnostic ability of cervical cancer and CIN, with a sensitivity of 70.97% and a specificity of 73.68%.

CONCLUSIONS

sNRP-1 in circulating can serve as a possible valuable diagnostic biomarker for cervical cancer and CIN.

Для цитирования: Yang Shouhua, Cheng Henghui, Huang Zaiju, Wang Xiaoling, Wan Yinglu, Cai Jing, Wang Zehua. Circulating soluble neuropilin-1 in patients with early cervical cancer and cervical intraepithelial neoplasia can be used as a valuable diagnostic biomarker.. Disease markers. 2015. DOI: 10.1155/2015/506428.

Предметные рубрики MeSH

Adult Aged Biomarkers, Tumor Case-Control Studies Female Humans Middle Aged Neuropilin-1 Uterine Cervical Neoplasms Uterine Cervical Dysplasia

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