Comment on: Association Between Complex Indices of Blood Cell Types and Lipid Levels With All-Cause, Cardiovascular Mortality in Hemodialysis Patients: A Multicenter Retrospective Study.

We reviewed the study by Chen et al. on the association between blood cell indices, lipid levels, and mortality in hemodialysis patients. While the study provides valuable insights, several limitations affect its generalizability and validity. The data were limited to four centers within a single country, and key confounders-such as lifestyle, psychological factors, medication use, and nutritional status-were not addressed. Additionally, the findings are not applicable to patients on other dialysis modalities. We recommend future multicenter studies that incorporate broader populations, account for confounding variables, and include validated nutritional assessment tools to better understand mortality risks in this population.