American journal of kidney diseases : the official journal of the National Kidney Foundation · 2012
Adenovirus-induced interstitial nephritis following umbilical cord blood transplant for chronic lymphocytic leukemia.
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Keddis Mira, Leung Nelson, Herrmann Sandra, El-Zoghby Ziad, Sethi Sanjeev
Аннотация
We present a case of a 27-year-old man who received an unrelated donor umbilical cord blood transplant for chronic lymphocytic leukemia. His postsurgery course was complicated by acute kidney injury, hemorrhagic cystitis, and pancytopenia. Transjugular kidney biopsy showed interstitial nephritis. Viral inclusions were present in tubular epithelial cells, and in situ hybridization studies confirmed the presence of adenovirus. Kidney function improved after a short course of cidofovir. Adenovirus-induced interstitial nephritis should be considered in the differential diagnosis in all cases of interstitial nephritis occurring in immunocompromised patients.
Предметные рубрики MeSH
Acute Kidney InjuryAdenoviridae InfectionsAdultAntineoplastic Combined Chemotherapy ProtocolsCidofovirCord Blood Stem Cell TransplantationCytosineFetal BloodFollow-Up StudiesHumansImmunocompromised HostLeukemia, Lymphocytic, Chronic, B-CellMaleNephritis, InterstitialOrganophosphonatesRisk AssessmentSeverity of Illness IndexTreatment OutcomeUnrelated DonorsViremia