Open medicine (Warsaw, Poland) · 2026
Therapeutic potential of vitamin D in improving antioxidant defense and blood rheology in a rat model of experimental diabetes mellitus.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Sakhanberidze Nino, Namoradze Manana, Charkviani Nino, Mantskava Maia, Momtselidze Nana, Delibashvili Davit, Gamkrelidze Natia
Аннотация
OBJECTIVES: To evaluate the preventive and corrective effects of vitamin D on antioxidant defense and blood rheology in rats with streptozotocin (STZ)-induced diabetes mellitus.
METHODS: Forty male rats (10 weeks old, ∼200 g) were randomly assigned to four groups: Group I - Intact controls; Group II - Diabetic rats (STZ only); Group III - Preventive (vitamin D for 14 days before STZ and continued throughout the experiment); Group IV - Therapeutic (vitamin D from day 3 post-STZ). DM was induced with streptozotocin (30 mg/kg), and vitamin D was administered orally at 300 IU/day, according to a previous dose-control experiment. Data from the 21st experimental day were evaluated. Blood samples collected at this point were used to determine catalase (CAT), superoxide dismutase (SOD), and blood rheological parameters.
RESULTS: Vitamin D supplementation enhanced antioxidant-related parameters and improved blood rheological indices, particularly when administered therapeutically.
CONCLUSIONS: Vitamin D shows therapeutic potential in attenuating oxidative imbalance and improving blood rheology in streptozotocin-induced diabetes mellitus.
METHODS: Forty male rats (10 weeks old, ∼200 g) were randomly assigned to four groups: Group I - Intact controls; Group II - Diabetic rats (STZ only); Group III - Preventive (vitamin D for 14 days before STZ and continued throughout the experiment); Group IV - Therapeutic (vitamin D from day 3 post-STZ). DM was induced with streptozotocin (30 mg/kg), and vitamin D was administered orally at 300 IU/day, according to a previous dose-control experiment. Data from the 21st experimental day were evaluated. Blood samples collected at this point were used to determine catalase (CAT), superoxide dismutase (SOD), and blood rheological parameters.
RESULTS: Vitamin D supplementation enhanced antioxidant-related parameters and improved blood rheological indices, particularly when administered therapeutically.
CONCLUSIONS: Vitamin D shows therapeutic potential in attenuating oxidative imbalance and improving blood rheology in streptozotocin-induced diabetes mellitus.