The aging male : the official journal of the International Society for the Study of the Aging Male · 2025
The association between lipid accumulation product and erectile dysfunction in hypertensive and diabetic men: a cross-sectional analysis of NHANES 2001-2004.
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Yu Maobin, Li Ze, Zeng Hongsen, Ma Jian, Deng Hang, Liu Meijun, Zhang Tao, Xu Zilong, Zhang Peihai
Аннотация
BACKGROUND: Erectile dysfunction (ED) is associated with metabolic disorders like hypertension and diabetes. The lipid accumulation product (LAP), a marker of visceral fat and dyslipidemia, has not been well studied in relation to ED in these populations. This study examined the relationship between LAP and ED.
METHODS: A cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES) 2001-2004 data included 756 men with hypertension or diabetes. Weighted multivariable logistic regression and restricted cubic spline (RCS) analysis evaluated LAP-ED associations, with subgroup analysis for effect modification.
RESULTS: ED prevalence was 43.65% (330/756). LAP correlated positively with ED risk (continuous: OR = 1.005, 95%CI:1.000-1.005). Highest vs lowest LAP quartile (Q4 vs Q1) showed 2.92-fold higher ED risk (OR = 2.92, 95%CI:1.21-7.06). RCS analysis indicated linear association (P for non-linearity = 0.290). Subgroup analysis showed no significant interactions.
CONCLUSION: This study demonstrates a positive correlation between LAP and ED in men with diabetes or hypertension; further studies are needed to confirm findings and explore mechanisms.
METHODS: A cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES) 2001-2004 data included 756 men with hypertension or diabetes. Weighted multivariable logistic regression and restricted cubic spline (RCS) analysis evaluated LAP-ED associations, with subgroup analysis for effect modification.
RESULTS: ED prevalence was 43.65% (330/756). LAP correlated positively with ED risk (continuous: OR = 1.005, 95%CI:1.000-1.005). Highest vs lowest LAP quartile (Q4 vs Q1) showed 2.92-fold higher ED risk (OR = 2.92, 95%CI:1.21-7.06). RCS analysis indicated linear association (P for non-linearity = 0.290). Subgroup analysis showed no significant interactions.
CONCLUSION: This study demonstrates a positive correlation between LAP and ED in men with diabetes or hypertension; further studies are needed to confirm findings and explore mechanisms.