Clinical efficacy of Chinese traditional herbal medicine (Fufang Xuanju capsule) on males of late-onset hypogonadism presenting with sexual dysfunction.

This study aimed to assess the efficacy and safety of Fufang Xuanju capsule in males with late-onset hypogonadism (LOH) complaining of sexual dysfunction during 3 months period. We identified the patients through questionnaires and laboratory examinations. Patients in the treatment group (n = 57) and placebo group (n = 50) received Fufang Xuanju capsules (3.78 g) or placebo capsules daily for 3 months, respectively. After treatment, the plasma total testosterone of both groups sustained, however, libido and erectile dysfunction in patients of the treatment group but not placebo group were significantly improved, measured by elevated scores of International Index of Erectile Function-5. The overall efficacy rate of Fufang Xuanju capsule for LOH was 71.9%. The most striking clinical effects were observed in patients exhibiting mild and moderate erectile dysfunction. No severe adverse effects were observed during the period of study. The remaining parameters such as total prostate-specific antigen, prostate volume and uroflow rate remained stable. Fufang Xuanju capsule proves to be an effective and safe treatment in a short time to alleviate symptoms of sexual dysfunction in LOH patients, especially in those exhibiting mild and moderate erectile dysfunction. Little effect on the level of total testosterone makes it well suitable for LOH patients which have contraindications of testosterone replacement therapy.