International journal of radiation oncology, biology, physics · 2003
Three-dimensional conformal radiotherapy for paranasal sinus carcinoma: clinical results for 25 patients.
Оценочное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Padovani Laetitia, Pommier Pascal, Clippe S Sébastien, Martel-Lafay Isabelle, Malet Claude, Poupart Marc, Zrounba Philippe, Ceruse Philippe, Desmes Sophie, Carrie Christian, Montbarbon Xavier, Ginestet Chantal
Аннотация
PURPOSE: To assess local control, survival, and clinical and dosimetric prognostic factors in 25 patients with locally advanced maxillary or ethmoid sinus carcinoma treated by three-dimensional conformal radiotherapy (RT).
MATERIALS AND METHODS: Surgery was performed in 22 patients and was macroscopically complete in 16. Seven patients received chemotherapy (concomitant with RT in four). The following quality indexes were defined for the 95% and 90% isodoses: tumor conformity index, normal tissue conformity index, and global conformity index.
RESULTS: The median radiation dose to the planned treatment volume was 63 Gy, with a minimal dose of 60 Gy, except in 2 patients whose cancer progressed during RT. The maximal doses tolerated by the structures involved in vision were respected, except for tumors that involved the optic nerve. After a median follow-up of 25 months, 14 local tumor recurrences developed. The major prognostic factors were central nervous system involvement by disease and the presence of nonresectable tumors. The radiation dose and tumor conformity index value were not significant prognostic indicators. Two patients died of acute infectious toxicity, and two developed late ipsilateral ocular toxicity.
CONCLUSIONS: Improving local control remains the main challenge in RT for paranasal tumors.
MATERIALS AND METHODS: Surgery was performed in 22 patients and was macroscopically complete in 16. Seven patients received chemotherapy (concomitant with RT in four). The following quality indexes were defined for the 95% and 90% isodoses: tumor conformity index, normal tissue conformity index, and global conformity index.
RESULTS: The median radiation dose to the planned treatment volume was 63 Gy, with a minimal dose of 60 Gy, except in 2 patients whose cancer progressed during RT. The maximal doses tolerated by the structures involved in vision were respected, except for tumors that involved the optic nerve. After a median follow-up of 25 months, 14 local tumor recurrences developed. The major prognostic factors were central nervous system involvement by disease and the presence of nonresectable tumors. The radiation dose and tumor conformity index value were not significant prognostic indicators. Two patients died of acute infectious toxicity, and two developed late ipsilateral ocular toxicity.
CONCLUSIONS: Improving local control remains the main challenge in RT for paranasal tumors.
Предметные рубрики MeSH
AdenocarcinomaAdultAgedAged, 80 and overCarcinomaCarcinoma, Squamous CellDisease ProgressionDisease-Free SurvivalDose-Response Relationship, RadiationEthmoid SinusEye InjuriesFemaleFollow-Up StudiesHumansImaging, Three-DimensionalLife TablesMaleMaxillary Sinus NeoplasmsMiddle AgedNeoplasm MetastasisNeoplasm Recurrence, LocalOptic Nerve InjuriesParanasal Sinus NeoplasmsRadiation InjuriesRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, ConformalSurvival AnalysisTreatment Outcome