Veterinary world · 2024
Protective effects of Delonix regia and gum Arabic against aluminum chloride-induced toxicity in male Albino Rats.
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Al-Doaiss Amin A, Alshehri Mohammed A, Shati Ali A, Almaawari Ali M, Al-Shahrani Hamad S, Saeed Abdulaziz M, Al-Ghamdi Abdulaziz M, Al-Shahrani Abdulaziz S, Almansour Muteb H, El-Mansi Ahmed A, Al-Zharani Mohammed, Mubarak Mohammed, Ali Montaser Elsayed
Аннотация
BACKGROUND AND AIM: Aluminum (AL) is commonly found in food, drinking, air, and soil and it can be a serious contaminant in varying amounts. Therefore, this study investigated the biochemical and histological hazardous reactions to aluminum chloride (AlCl3) and the efficiency of the methanol extract of Delonix regia aerial parts with gum Arabic (GA) as anti-toxic therapies to return to a natural state after AlCl3 exposure.
MATERIALS AND METHODS: A total of 20 male Wistar rats were randomly divided into four equal groups. (i) CG: Served as a control group. (ii) AlCl3: Rats were exposed to 80 mg/kg/body weight (BW) AlCl3. (iii) AlCl3 + D. regia/GA: rats were administered AlCl3 + 100 mg/kg B.W. with 15% BW of D. regia and GA, respectively. (iv) D. regia/GA: Rats were administered 100 mg/kg B.W. with 15% BW D. regia and GA, respectively. The experimental treatment was administered for 30 days. On the 30th day, blood biochemical parameters were assessed, and specimens from the liver and kidney were collected and stored in a neutral buffer with 10% formalin until immediate histopathological examination after euthanasia.
RESULTS: This study revealed a significant increase in white blood cells and platelets after AlCl3 exposure compared with CG, while there was a decrease in red blood cells, hemoglobin, hematocrit, and mean corpuscular volume. Treatment with D. regia/GA improved lymphocytes, monocytes, eosinophils, and basophils. Furthermore, the animals exposed to AlCl3 showed a significant increase in aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase compared with CG, whereas AlCl3 + D. regia/GA treatment improved these activities. In addition, the rats exposed to AlCl3 had significantly increased glucose, lipase, amylase, triglyceride, cholesterol, high-density lipoprotein, and low-density lipoprotein levels, and D. regia/GA treatment significantly improved these levels compared with AlCl3. This study reported no significant differences in Ca and Na concentrations among groups, but rats exposed to AlCl3 had elevated K, Cl, and Mg levels, whereas D. regia/GA treatment improved these levels.
CONCLUSION: The co-administration of the methanolic extract of D. regia with GA can protect against AlCl3 toxicity.
MATERIALS AND METHODS: A total of 20 male Wistar rats were randomly divided into four equal groups. (i) CG: Served as a control group. (ii) AlCl3: Rats were exposed to 80 mg/kg/body weight (BW) AlCl3. (iii) AlCl3 + D. regia/GA: rats were administered AlCl3 + 100 mg/kg B.W. with 15% BW of D. regia and GA, respectively. (iv) D. regia/GA: Rats were administered 100 mg/kg B.W. with 15% BW D. regia and GA, respectively. The experimental treatment was administered for 30 days. On the 30th day, blood biochemical parameters were assessed, and specimens from the liver and kidney were collected and stored in a neutral buffer with 10% formalin until immediate histopathological examination after euthanasia.
RESULTS: This study revealed a significant increase in white blood cells and platelets after AlCl3 exposure compared with CG, while there was a decrease in red blood cells, hemoglobin, hematocrit, and mean corpuscular volume. Treatment with D. regia/GA improved lymphocytes, monocytes, eosinophils, and basophils. Furthermore, the animals exposed to AlCl3 showed a significant increase in aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase compared with CG, whereas AlCl3 + D. regia/GA treatment improved these activities. In addition, the rats exposed to AlCl3 had significantly increased glucose, lipase, amylase, triglyceride, cholesterol, high-density lipoprotein, and low-density lipoprotein levels, and D. regia/GA treatment significantly improved these levels compared with AlCl3. This study reported no significant differences in Ca and Na concentrations among groups, but rats exposed to AlCl3 had elevated K, Cl, and Mg levels, whereas D. regia/GA treatment improved these levels.
CONCLUSION: The co-administration of the methanolic extract of D. regia with GA can protect against AlCl3 toxicity.