American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025
Effectiveness of Inpatient Rehabilitation for Older Adults Soon After Dialysis Initiation to Improve Health Outcomes.
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Van Loon Ismay, Kajawo Shepherd, McArthur Eric, Nash Danielle M, Rodrigues Lima F, Dixon Stephanie N, Garg Amit X, Fleet Jamie L, Welk Blayne, Jassal S Vanita
Аннотация
RATIONALE & OBJECTIVE: Multiple studies have shown that older adults' initiation of dialysis is associated with functional decline often within months of starting treatment. This functional impairment has been associated with a 2- to 4-fold higher risk of mortality and morbidity. This study assessed whether rehabilitation within the first few months after starting dialysis may improve physical function and reduce the rates of hospitalization and mortality.
STUDY DESIGN: Retrospective matched cohort study.
SETTING & PARTICIPANTS: Individuals in Ontario, Canada, aged≥66 years initiating maintenance dialysis whose health care data were recorded by ICES, which captures administrative health data for the population of Ontario.
EXPOSURE: Inpatient rehabilitation care within 6 months of starting dialysis.
OUTCOME: Change in the Functional Independence Measure (FIM) score during the rehabilitation hospitalization among those receiving rehabilitation. Counts of hospital days, rates of admission to hospitals and long-term care facilities, and mortality over 1 year after the index date for comparisons of those who received rehabilitation to those who did not.
ANALYTICAL APPROACH: Patients receiving rehabilitation and 3 times as many patients not receiving rehabilitation were matched using a propensity score logistic regression model. Outcomes among those who did and did not receive rehabilitation were compared using Cox proportional hazards models and the Cochran-Mantel-Haenszel test for binary outcomes.
RESULTS: Among those undergoing rehabilitation, FIM scores improved from 76±17 (SD) at admission, to 98±19 (SD) by discharge (P<0.001). We matched 1,287 of 1,567 patients (82%) admitted for rehabilitation within 6 months of dialysis with 3,861 patients who did not receive rehabilitation. The patients undergoing rehabilitation had similar 1-year mortality rates to the matched comparison population (27% vs 25%, P=0.5) and had higher hospitalization rates and length-of-stay. Six percent of patients in both groups were admitted to a long-term care facility within the 1-year follow-up (P=0.7).
LIMITATIONS: Potential for residual confounding due to the use of administrative data.
CONCLUSIONS: These data suggest that patients may benefit physically from rehabilitation around the time of starting dialysis. Hospitalization was slightly higher in those undergoing rehabilitation; however, unlike previously published data on those with low baseline functional status, mortality was similar across both groups.
STUDY DESIGN: Retrospective matched cohort study.
SETTING & PARTICIPANTS: Individuals in Ontario, Canada, aged≥66 years initiating maintenance dialysis whose health care data were recorded by ICES, which captures administrative health data for the population of Ontario.
EXPOSURE: Inpatient rehabilitation care within 6 months of starting dialysis.
OUTCOME: Change in the Functional Independence Measure (FIM) score during the rehabilitation hospitalization among those receiving rehabilitation. Counts of hospital days, rates of admission to hospitals and long-term care facilities, and mortality over 1 year after the index date for comparisons of those who received rehabilitation to those who did not.
ANALYTICAL APPROACH: Patients receiving rehabilitation and 3 times as many patients not receiving rehabilitation were matched using a propensity score logistic regression model. Outcomes among those who did and did not receive rehabilitation were compared using Cox proportional hazards models and the Cochran-Mantel-Haenszel test for binary outcomes.
RESULTS: Among those undergoing rehabilitation, FIM scores improved from 76±17 (SD) at admission, to 98±19 (SD) by discharge (P<0.001). We matched 1,287 of 1,567 patients (82%) admitted for rehabilitation within 6 months of dialysis with 3,861 patients who did not receive rehabilitation. The patients undergoing rehabilitation had similar 1-year mortality rates to the matched comparison population (27% vs 25%, P=0.5) and had higher hospitalization rates and length-of-stay. Six percent of patients in both groups were admitted to a long-term care facility within the 1-year follow-up (P=0.7).
LIMITATIONS: Potential for residual confounding due to the use of administrative data.
CONCLUSIONS: These data suggest that patients may benefit physically from rehabilitation around the time of starting dialysis. Hospitalization was slightly higher in those undergoing rehabilitation; however, unlike previously published data on those with low baseline functional status, mortality was similar across both groups.