International journal of nephrology · 2022
Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Ayza Muluken Altaye, Zewdie Kaleab Alemayehu, Yigzaw Elias Fitsum, Ayele Solomon Gashaw, Tesfaye Bekalu Amare, Tafere Gebrehiwot Gebremedhin, Abrha Muzey Gebreyohannes
Аннотация
Cyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful drugs with wide arrays of clinical activity. It has been in use for several types of cancer treatments and as an immunosuppressive agent for the management of autoimmune and immune-mediated diseases. Nowadays, its clinical use is limited due to various toxicities, including nephrotoxicity. Even though the mechanisms are not well understood, cyclophosphamide-induced nephrotoxicity is reported to be mediated through oxidative stress. This review focuses on the potential role of natural and plant-derived antioxidants in preventing cyclophosphamide-induced nephrotoxicity.