Comprehensive analysis of resting tremor based on acceleration signals of patients with Parkinson's disease.

BACKGROUND

Resting tremor is an essential characteristic in patients suffering from Parkinson's disease (PD).

OBJECTIVE

Quantification and monitoring of tremor severity is clinically important to help achieve medication or rehabilitation guidance in daily monitoring.

METHODS

Wrist-worn tri-axial accelerometers were utilized to record the long-term acceleration signals of PD patients with different tremor severities rated by Unified Parkinson's Disease Rating Scale (UPDRS). Based on the extracted features, three kinds of classifiers were used to identify different tremor severities. Statistical tests were further designed for the feature analysis.

RESULTS

The support vector machine (SVM) achieved the best performance with an overall accuracy of 94.84%. Additional feature analysis indicated the validity of the proposed feature combination and revealed the importance of different features in differentiating tremor severities.

CONCLUSION

The present work obtains a high-accuracy classification in tremor severity, which is expected to play a crucial role in PD treatment and symptom monitoring in real life.