Медицинская библиотека · Hypertension in pregnancy · 2022

IGFBP1 inhibits the invasion, migration, and apoptosis of HTR-8/SVneo trophoblast cells in preeclampsia.

Li Xiujuan, Li Chenxi, Wang Ye, Cai Jianxing, Zhao Li, Su Zhiying, Ye Huiming

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Аннотация

OBJECTIVE

To investigate the effects and underlying mechanisms of IGFBP1 on the biological functions of trophoblasts in simulated preeclampsia.

METHODS

IGFBP1 expression in placenta was determined by immunohistochemistry. HTR-8/SVneo cells were stimulated with/without IGFBP1-overexpression and hypoxia-reoxygenation, and the proliferation, invasion, migration, and apoptosis were detected by CCK8, transwell, and flow cytometry, respectively.

RESULTS

IGFBP1 expression was increased in placenta of preeclampsia. IGFBP1 overexpression inhibited proliferation, invasion, migration, and apoptosis of HTR-8/SVneo cells and induced MMP-26 expression with/without hypoxia-reoxygenation challenge.

CONCLUSION

IGFBP1 affects biological functions of trophoblasts, and it may play a role in pathophysiology of preeclampsia by inducing MMP-26.

Для цитирования: Li Xiujuan, Li Chenxi, Wang Ye, Cai Jianxing, Zhao Li, Su Zhiying, Ye Huiming. IGFBP1 inhibits the invasion, migration, and apoptosis of HTR-8/SVneo trophoblast cells in preeclampsia.. Hypertension in pregnancy. 2022. DOI: 10.1080/10641955.2022.2033259.

Предметные рубрики MeSH

Apoptosis Cell Line Cell Movement Cell Proliferation Female Humans Insulin-Like Growth Factor Binding Protein 1 Placenta Pre-Eclampsia Pregnancy Trophoblasts

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