Медицинская библиотека · Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2001

[Expression of bcl-2 and Bax genes in facial neurons and their regulation of neuron apoptosis following facial neurotmesis in rats].

Yang J, Fang Z, Li H, Zhang C

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Аннотация

OBJECTIVE

The aim of this study is to investigate the relationship between the expression changes of bcl-2 and Bax genes and their functions in facial neuronal apoptosis after amputating the facial nerve.

METHODS

Rats were randomized into two groups, including the experimental and the control group. The changes of expression of bcl-2 and Bax genes in the facial neurons and facial neuronal apoptosis were observed after the facial nerve amputation using the methods of ABC immunohistochemical staining and TUNEL.

RESULTS

The expression of bcl-2 and Bax genes and the apoptosis of facial neurons were significantly higher in the experimental group than those of the control group from the 3rd to 21st day after amputation, but the bcl-2/Bax significantly decreased compared with that of the control group.

CONCLUSION

This indicated that bcl-2 and Bax might play an important regulation role in the process of facial neurons apoptosis following facial nerve amputation.

Для цитирования: Yang J, Fang Z, Li H, Zhang C. [Expression of bcl-2 and Bax genes in facial neurons and their regulation of neuron apoptosis following facial neurotmesis in rats].. Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology. 2001.

Предметные рубрики MeSH

Animals Apoptosis Facial Nerve Injuries Gene Expression Regulation Neurons Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 Rats Rats, Wistar bcl-2-Associated X Protein

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