Development of 3D Porphyrinic Covalent Organic Frameworks for Enhanced Sono-Photodynamic Therapy against Prostate Cancer.

This study focuses on designing and developing a novel three-dimensional porphyrinic covalent organic framework (3D-Por-COF) to enhance anticancer sono-photodynamic therapy (SPDT). Leveraging the unique structural advantages of 3D COFs, this work addresses the limitations of traditional 2D-Por-COFs, particularly regarding reactive oxygen species (ROS) production and therapeutic efficacy. The newly developed 3D-Por-COF demonstrated significantly higher ROS generation under combined sonodynamic and photodynamic conditions, leading to an improved therapeutic effect against prostate cancer cells. Comparative analyses with 2D-Por-COF revealed that the 3D architecture not only enhances ROS production but also offers superior penetration and accumulation in tumor tissues, resulting in more effective anticancer SPDT. The promising results of this study indicate that 3D-Por-COFs could be pivotal in the development of next-generation cancer treatment strategies, particularly in overcoming the challenges associated with traditional therapies.