International journal of clinical and experimental medicine · 2015
Urinary BLCA1 is specific for urothelial cancer detection in Chinese ethnicity.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Lujia, Feng Chenchen, Ding Guanxiong, Jiang Haowen, Ding Qiang, Wu Zhong
Аннотация
AIM: To study the potential of BLCA1 for detection of urothelial cancer including urinary bladder cancer (UBC) and upper tract urothelial cancer (UTUC).
METHOD: An antibody for BLCA1 was generated and indirect ELISA was used to detect urinary BLCA1 level. Clinicopathological parameters were studied for the association with BLCA1 level. Urine samples from UBC and UTUC patients, together with cases with other urological disorders were collected and tested.
RESULTS: Urinary BLCA1 level in UBC and UTUC patients were significantly higher than that in normal controls. This was also proven when urothelial cancers were grouped as a whole, where as the level did not differ between UBC and UTUC samples. BLCA1 was also significantly higher in urothelial cancer samples compared to other urological disorders such as patients with long-dwelling catheter, glandular cystitis, BPH and other benign conditions. Cut-off value at 0.0009 OD/μg yielded a sensitivity of 92.7% and a specificity of 92.9% for UBC.
CONCLUSION: Urinary BLCA1 is a promising marker for urothelial cancers including UBC and UTUC with high sensitivity and specificity.
METHOD: An antibody for BLCA1 was generated and indirect ELISA was used to detect urinary BLCA1 level. Clinicopathological parameters were studied for the association with BLCA1 level. Urine samples from UBC and UTUC patients, together with cases with other urological disorders were collected and tested.
RESULTS: Urinary BLCA1 level in UBC and UTUC patients were significantly higher than that in normal controls. This was also proven when urothelial cancers were grouped as a whole, where as the level did not differ between UBC and UTUC samples. BLCA1 was also significantly higher in urothelial cancer samples compared to other urological disorders such as patients with long-dwelling catheter, glandular cystitis, BPH and other benign conditions. Cut-off value at 0.0009 OD/μg yielded a sensitivity of 92.7% and a specificity of 92.9% for UBC.
CONCLUSION: Urinary BLCA1 is a promising marker for urothelial cancers including UBC and UTUC with high sensitivity and specificity.