Spatial distribution of coronary artery thromboses in patients with chronic kidney disease: implications for diagnosis and treatment.

The study by Charytan et al. provides us with a better understanding of the pathophysiology of acute myocardial infarction in patients with chronic kidney disease (CKD). One important observation is that more proximal plaque rupture results in poorer outcome in patients with CKD; clinicians should target these patients for aggressive revascularization to try to improve outcomes. This study will hopefully lead to additional research and help us develop more effective local and systemic therapies for patients with CKD.