Fukushima journal of medical science · 2025
Serum low density lipoprotein cholesterol / high density lipoprotein cholesterol ratio predicts lower urinary tract dysfunction related dyslipidemia.
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Harigane Yuki, Akaihata Hidenori, Yaginuma Kei, Imai Hitomi, Meguro Satoru, Takinami Ruriko, Matsuoka Kanako, Hata Junya, Sato Yuichi, Ogawa Soichiro, Kojima Yoshiyuki
Аннотация
OBJECTIVES: To investigate the effect of dyslipidemia on the lower urinary tract function by examining the LDL-C/HDL-C ratio in patients without bladder outlet obstruction (BOO).
METHODS: Patients who underwent urodynamic study before robot-assisted radical prostatectomy were included. Exclusion criteria were diabetes mellitus (HbA1c > 6.2%) and BOO (Schäfer nomogram obstruction III - V). The association between the preoperative LDL-C/HDL-C ratio and urodynamic findings were analyzed. Patients were divided into two groups based on Schäfer nomogram: weak contraction group (W-, W+, N-) and strong contraction group (N+, ST) to assess the relationship between the LDL-C/HDL-C ratio and bladder contraction.
RESULTS: A total of 52 patients entered the study. The LDL-C/HDL-C ratio was 2.4 ± 0.8. The preoperative international prostate symptom score was mild (6.7 ± 5.6). Voided volume was significantly positively associated with the LDL-C/HDL-C ratio (P=0.041). The LDL-C/HDL-C ratio was significantly less in the strong contraction group than in the weak contraction group (P=0.047). Receiver operating characteristic (ROC) analysis showed a cut-off value of 2.15 for the LDL-C/HDL-C ratio in predicting weak bladder contraction.
CONCLUSIONS: Dyslipidemia-induced lower urinary tract dysfunction (LUTD) showed less bladder contractility with larger voided volume. The LDL-C/HDL-C ratio ≥ 2.15 may be a useful marker of dyslipidemia-induced LUTD.
METHODS: Patients who underwent urodynamic study before robot-assisted radical prostatectomy were included. Exclusion criteria were diabetes mellitus (HbA1c > 6.2%) and BOO (Schäfer nomogram obstruction III - V). The association between the preoperative LDL-C/HDL-C ratio and urodynamic findings were analyzed. Patients were divided into two groups based on Schäfer nomogram: weak contraction group (W-, W+, N-) and strong contraction group (N+, ST) to assess the relationship between the LDL-C/HDL-C ratio and bladder contraction.
RESULTS: A total of 52 patients entered the study. The LDL-C/HDL-C ratio was 2.4 ± 0.8. The preoperative international prostate symptom score was mild (6.7 ± 5.6). Voided volume was significantly positively associated with the LDL-C/HDL-C ratio (P=0.041). The LDL-C/HDL-C ratio was significantly less in the strong contraction group than in the weak contraction group (P=0.047). Receiver operating characteristic (ROC) analysis showed a cut-off value of 2.15 for the LDL-C/HDL-C ratio in predicting weak bladder contraction.
CONCLUSIONS: Dyslipidemia-induced lower urinary tract dysfunction (LUTD) showed less bladder contractility with larger voided volume. The LDL-C/HDL-C ratio ≥ 2.15 may be a useful marker of dyslipidemia-induced LUTD.