Acta cirurgica brasileira · 2012
Influence of arterial hypertension on colonic healing in rats.
СтатьяНазвание и аннотация: Перевод в очереди
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Ortolan Gilberto Luiz, Biondo-Simões Maria de Lourdes Pessole, Fávero Giovani Marino, Fernandes Daniel, Montemór Netto Mário Rodrigues, Olchanheski Luiz Renato
Аннотация
PURPOSE: Evaluation of colonic healing in spontaneously hypertensive rats.
METHODS: Fifty male, young and inbred rats were used. Twenty-five Wistar Kyoto rats (WKY) as control and twenty-five spontaneously hypertensive rats (SHR) as an experimental group. Colotomy and bowel suture at 2.5 cm from the peritoneal reflection were performed. All animals were allocated randomly into sub-groups for review at the third, seventh and fourteenth days after surgery. We evaluated the concentration of angiotensin II, the burst pressure, epithelialization, the organization of the tunics of the bowel wall, inflammatory response and collagen deposition.
RESULTS: The burst pressure, epithelialization, organization of the tunics and collagen deposition was not significant between groups. The inflammatory reaction was more intense in the control group on the third postoperative day (p=0.023) as the experimental group on the remaining time.
CONCLUSION: Systemic arterial hypertension in rats did not influence significantly the healing process of colonic anastomoses.
METHODS: Fifty male, young and inbred rats were used. Twenty-five Wistar Kyoto rats (WKY) as control and twenty-five spontaneously hypertensive rats (SHR) as an experimental group. Colotomy and bowel suture at 2.5 cm from the peritoneal reflection were performed. All animals were allocated randomly into sub-groups for review at the third, seventh and fourteenth days after surgery. We evaluated the concentration of angiotensin II, the burst pressure, epithelialization, the organization of the tunics of the bowel wall, inflammatory response and collagen deposition.
RESULTS: The burst pressure, epithelialization, organization of the tunics and collagen deposition was not significant between groups. The inflammatory reaction was more intense in the control group on the third postoperative day (p=0.023) as the experimental group on the remaining time.
CONCLUSION: Systemic arterial hypertension in rats did not influence significantly the healing process of colonic anastomoses.