Fertility and sterility · 2013
Progesterone level at oocyte retrieval predicts in vitro fertilization success in a short-antagonist protocol: a prospective cohort study.
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Nayak Shweta, Ochalski Melanie E, Fu Bo, Wakim Kathryn-Mary, Chu Tian Jao, Dong Xinxin, Wakim Anthony N
Аннотация
OBJECTIVE: To evaluate the distribution of P levels on the day of oocyte retrieval as it relates to pregnancy outcome in an antagonist protocol, which may be at higher risk for elevated P levels.
DESIGN: Prospective cohort study.
SETTING: Academic IVF center.
PATIENT(S): One hundred eighty-six women undergoing controlled ovarian hyperstimulation with an antagonist protocol.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Implantation, pregnancy, and spontaneous abortion rates were collected.
RESULT(S): Implantation rate (positive hCG 14 days after ET) and pregnancy rate were significantly higher when the P level was <12 ng/mL on the day of oocyte retrieval. Miscarriage rates were higher when the P level was ≥12 ng/mL, although this did not reach statistical significance.
CONCLUSION(S): Elevated P on the day of oocyte retrieval is associated with significantly lower implantation and ongoing pregnancy rates. This is the first study to date to both uncover the distribution of P on the day of oocyte retrieval in an antagonist cycle and determine the impact an elevation may have on pregnancy outcome.
DESIGN: Prospective cohort study.
SETTING: Academic IVF center.
PATIENT(S): One hundred eighty-six women undergoing controlled ovarian hyperstimulation with an antagonist protocol.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Implantation, pregnancy, and spontaneous abortion rates were collected.
RESULT(S): Implantation rate (positive hCG 14 days after ET) and pregnancy rate were significantly higher when the P level was <12 ng/mL on the day of oocyte retrieval. Miscarriage rates were higher when the P level was ≥12 ng/mL, although this did not reach statistical significance.
CONCLUSION(S): Elevated P on the day of oocyte retrieval is associated with significantly lower implantation and ongoing pregnancy rates. This is the first study to date to both uncover the distribution of P on the day of oocyte retrieval in an antagonist cycle and determine the impact an elevation may have on pregnancy outcome.