Journal of natural science, biology, and medicine · 2015
Antioxidant and protective effects of Phytocee(™) against carbon tetrachloride-induced oxidative stress.
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Joseph Joshua Allan, Radhakrishnan Uma, Mutyala Sridhar, Goudar Krishnagouda Shankargouda, Ayyappan Usha Parackal Thachappully, Agarwal Amit
Аннотация
BACKGROUND: This study evaluated the antioxidant potential of a polyherbal formulation (Phytocee(™)) in the rodent model.
MATERIALS AND METHODS: Four groups of rats (n = 6) were pretreated with Vitamin C (20 mg/kg) or Phytocee(™) (20, 100, and 200 mg/kg), respectively for 10 days. Oxidative stress in rat liver was induced by administration of carbon tetrachloride (CCl4) at 2 ml/kg as a single dose orally to all groups except the vehicle control group. After 24 h of administration of CCl4, hepatic levels of malondialdehyde (MDA), serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hepatic superoxide dismutase (SOD), catalase, and reduced glutathione (GSH) levels were evaluated.
RESULTS: Phytocee(™) administered groups at all the dose levels significantly reduced the hepatic MDA, serum ALT and AST levels with a marked increase in hepatic SOD and catalase as compared with CCl4 treated group.
CONCLUSION: The findings suggest that Phytocee(™) markedly reversed the effects of CCl4 induced oxidative stress and can be used as an antioxidant feed supplement.
MATERIALS AND METHODS: Four groups of rats (n = 6) were pretreated with Vitamin C (20 mg/kg) or Phytocee(™) (20, 100, and 200 mg/kg), respectively for 10 days. Oxidative stress in rat liver was induced by administration of carbon tetrachloride (CCl4) at 2 ml/kg as a single dose orally to all groups except the vehicle control group. After 24 h of administration of CCl4, hepatic levels of malondialdehyde (MDA), serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hepatic superoxide dismutase (SOD), catalase, and reduced glutathione (GSH) levels were evaluated.
RESULTS: Phytocee(™) administered groups at all the dose levels significantly reduced the hepatic MDA, serum ALT and AST levels with a marked increase in hepatic SOD and catalase as compared with CCl4 treated group.
CONCLUSION: The findings suggest that Phytocee(™) markedly reversed the effects of CCl4 induced oxidative stress and can be used as an antioxidant feed supplement.