Internal medicine (Tokyo, Japan) · 2018
A 10-year Follow-up Study of a Japanese Family with Ferroportin Disease A: Mild Iron Overload with Mild Hyperferritinemia Co-occurring with Hyperhepcidinemia May Be Benign.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Hayashi Hisao, Yano Motoyoshi, Urawa Naohito, Mizutani Akane, Hamaoka Shima, Araki Jun, Kojima Yuji, Naito Yutaka, Kato Ayako, Tatsumi Yasuaki, Kato Koichi
Аннотация
This is a 10-year follow-up study of a family with ferroportin disease A. The proband, a 59-year-old man showed no noteworthy findings with the exception of an abnormal iron level. The proband's 90-year-old father showed reduced abilities in gait and cognition; however, with the exception of his iron level, his biochemistry results were almost normal. Brain imaging showed age-matched atrophy and iron deposition. In both patients, the serum levels of ferritin and hepcidin25, and liver computed tomography scores declined over a 10-year period. These changes were mainly due to a habitual change to a low-iron diet. The iron disorder in this family was not associated with major organ damage.