Luminescence : the journal of biological and chemical luminescence · 2023
The hydrogen bond between tryptophan and the host molecule induced fluorescence enhancement.
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Yang Xi, Xue Ting, Zhao Ran, Liang Han-Ning, Chen De-Jun, Yuan Bin, Gu Xun-Gang, Shen Yong-Hui, Qin Ling
Аннотация
Tryptophan is one of important amino acids in the human body, therefore its detection is particularly important. The 3,5-bis(4-pyridyl)-4-amino-1,2,4-triazole (BPAT) organic molecule was designed to be used as fluorescence detectors to detect tryptophan molecules for the interaction between the host and the guest. BPAT shows good sensitivity and selectivity towards tryptophan compared with other amino acid molecules. The limit of detection obtained from formula 3δ/KSV is considered to be 5.43 × 10-7 mol/L. We speculated that this change is mainly caused by the hydrogen bond between tryptophan and the host molecule BPAT. This conjecture was verified by the controlled experiments with other host molecules.