BJOG : an international journal of obstetrics and gynaecology · 2004
Thrombophilia and stillbirth: possible connection by intrauterine growth restriction.
СтатьяНазвание и аннотация: Перевод в очереди
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Weiner Zeev, Beck-Fruchter Ronit, Weiss Amir, Hujirat Yasir, Shalev Eliezer, Shalev Stavit A
Аннотация
OBJECTIVE: To define the association between thrombophilia and unexplained stillbirth.
DESIGN: A case-control study.
SETTING: Obstetric department in a university affiliated hospital (Ha'Emek Medical Center, Afula).
POPULATION: A total of 53 women who delivered stillborns between March 1998 and June 2002 and 59 women with unremarkable obstetric history who delivered at the same period.
METHODS: Presence of genetic and acquired markers of thrombophilia was investigated.
MAIN OUTCOME MEASURE: Presence or absence of thrombophilia.
RESULTS: Thrombophilia was found in 34% of the women who delivered stillborns and in 20% of the 59 women with normal pregnancies (non-significant). However, significantly higher prevalence of thrombophilia (73%) was found in women who delivered small for gestational age stillborns compared with women who delivered normal birthweight stillborns (73%vs 18.4%, P < 0.0001).
CONCLUSIONS: There is no association between thrombophilia and stillbirth, overall. However, there is a clear association between thrombophilia and stillbirth of extremely growth restricted infants.
DESIGN: A case-control study.
SETTING: Obstetric department in a university affiliated hospital (Ha'Emek Medical Center, Afula).
POPULATION: A total of 53 women who delivered stillborns between March 1998 and June 2002 and 59 women with unremarkable obstetric history who delivered at the same period.
METHODS: Presence of genetic and acquired markers of thrombophilia was investigated.
MAIN OUTCOME MEASURE: Presence or absence of thrombophilia.
RESULTS: Thrombophilia was found in 34% of the women who delivered stillborns and in 20% of the 59 women with normal pregnancies (non-significant). However, significantly higher prevalence of thrombophilia (73%) was found in women who delivered small for gestational age stillborns compared with women who delivered normal birthweight stillborns (73%vs 18.4%, P < 0.0001).
CONCLUSIONS: There is no association between thrombophilia and stillbirth, overall. However, there is a clear association between thrombophilia and stillbirth of extremely growth restricted infants.