Atencion primaria · 2019
[Management of hyperglycaemia with non-insulin drugs in adult patients with type 2 diabetes].
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Álvarez-Guisasola Fernando, Orozco-Beltrán Domingo, Cebrián-Cuenca Ana M, Ruiz Quintero Manuel Antonio, Angullo Martínez Escarlata, Ávila Lachica Luis, Ortega Millán Carlos, Caride Miana Elena, Navarro-Pérez Jorge, Sagredo Perez Julio, Barrot de la Puente Joan, Cos Claramunt Francesc Xavier
Аннотация
Treatment of diabetes mellitus type2 (DM2) includes healthy eating and exercise (150minutes/week) as basic pillars. For pharmacological treatment, metformin is the initial drug except contraindication or intolerance; in case of poor control, 8 therapeutic families are available (6 oral and 2 injectable) as possible combinations. An algorithm and some recommendations for the treatment of DM2 are presented. In secondary cardiovascular prevention, it is recommended to associate an inhibitor of the sodium-glucose cotransporter type 2 (iSGLT2) or a glucagon-like peptide-1 receptor agonist (arGLP1) in patients with obesity. In primary prevention if the patient is obese or overweight metformin should be combined with iSGLT2, arGLP1, or inhibitors of type4 dipeptidylpeptidase (iDPP4). If the patient does not present obesity, iDPP4, iSGLT2 or gliclazide, sulfonylurea, recommended due to its lower tendency to hypoglycaemia, may be used.