Vitamin B6 modulates CD8+ T cell antitumor responses.

In this issue of Developmental Cell, Wu et al. report that the active form of vitamin B6, pyridoxal phosphate (PLP), enhances CD8+ T cell-dependent tumor clearance. Mechanistically, PLP maintains CD8+ T cells in a stemness-like state by inhibiting the nuclear translocation of BACH2. Here, we discuss these findings and their implications for cancer immunotherapy.