Medicina clinica · 2025
Renal donation: Acceptance criteria and their influence at 5 and 10years after donation.
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Nuñez Silvana Alejandra, Fernández Pehuén, Douthat Walter, de Arteaga Javier, Saad Emanuel José, de la Fuente Jorge, Chiurchiu Carlos
Аннотация
INTRODUCTION: Acceptance criteria for kidney donors (KDs) have become more flexible over time, raising questions about their long-term consequences. The objective of this study was to evaluate changes in the baseline characteristics of accepted KDs and to analyze their evolution after donation.
METHODS: A cohort study was conducted that included all KDs from our institution from 2010 to 2017. Baseline characteristics were compared by period and follow-up was carried out up to 10years after donation.
RESULTS: 169 KDs aged 45.6±12.2years were included, mostly women (63.9%). The main comorbidity they presented was obesity (29.6%) and controlled arterial hypertension (10.7%). KDs showed significant differences in estimated glomerular filtration rate (eGFR) with lower values in the last study period (P=.002). Progression to chronic kidney disease (CKD)III-a was 31% (95%CI: 23.5-39.6) and III-b 3.9% (95%CI: 0.5-7.2). Related risk factors were age (HRa=1.04; 95%CI: 1.01-1,07; P=.033) and pre-donation eGFR (HRa=0,97; 95%CI: 0.95-0,99; P=.028). No patient progressed to CKDIV, V or died during follow-up.
CONCLUSION: There were subtle changes in the characteristics of the accepted KR. Age and baseline eGFR were independent predictors of progression to CKDIII post-donation. The incidence of advanced CKD and mortality were null at 10years of post-donation follow-up, so it seems to be a safe procedure in our environment in the long term.
METHODS: A cohort study was conducted that included all KDs from our institution from 2010 to 2017. Baseline characteristics were compared by period and follow-up was carried out up to 10years after donation.
RESULTS: 169 KDs aged 45.6±12.2years were included, mostly women (63.9%). The main comorbidity they presented was obesity (29.6%) and controlled arterial hypertension (10.7%). KDs showed significant differences in estimated glomerular filtration rate (eGFR) with lower values in the last study period (P=.002). Progression to chronic kidney disease (CKD)III-a was 31% (95%CI: 23.5-39.6) and III-b 3.9% (95%CI: 0.5-7.2). Related risk factors were age (HRa=1.04; 95%CI: 1.01-1,07; P=.033) and pre-donation eGFR (HRa=0,97; 95%CI: 0.95-0,99; P=.028). No patient progressed to CKDIV, V or died during follow-up.
CONCLUSION: There were subtle changes in the characteristics of the accepted KR. Age and baseline eGFR were independent predictors of progression to CKDIII post-donation. The incidence of advanced CKD and mortality were null at 10years of post-donation follow-up, so it seems to be a safe procedure in our environment in the long term.