Internal medicine (Tokyo, Japan) · 2018
Successful Cord Blood Stem Cell Transplantation for Primary Cutaneous CD8-positive Aggressive Epidermotropic Cytotoxic T-cell Lymphoma Complicated with Cerebral Infiltration.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Ichikawa Satoshi, Fukuhara Noriko, Hatta Shunsuke, Himuro Masahito, Katsushima Hiroki, Nasu Kentaro, Ono Koya, Inokura Kyoko, Kobayashi Masahiro, Onishi Yasushi, Fujii Hiroshi, Ishizawa Kenichi, Ichinohasama Ryo, Harigae Hideo
Аннотация
A 16-year-old boy, who had been initially examined for bilateral blepharedema and slight eruption, presented with rapidly deteriorating symptoms in associating with headache and consciousness disturbance. He was diagnosed to have primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma (PCAE-CTL) by a biopsy of the skin and brain. After whole-brain radiation and some courses of chemotherapy, cord blood transplantation was performed with myeloablative conditioning. After transplantation, the cerebral dysfunction gradually improved. Disease remission was confirmed by the disappearance of any abnormal findings on electroencephalogram and magnetic resonance imaging. PCAE-CTL is reported to be an extremely aggressive disease with a poor prognosis, but the timely performance of cord blood transplantation is considered to be a promising treatment strategy.