Medicina clinica · 2025
Comparison of the efficacy of pharmacological interventions for the prevention of delirium: A systematic review and network meta-analysis.
Сравнительное исследованиеСтатьяNetwork Meta-AnalysisСистематический обзорНазвание и аннотация: Перевод в очереди
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Zhou Xiangwu, Yin Chengguo
Аннотация
BACKGROUND: In recent years, many pharmacological agents for the prevention of delirium have emerged; however, the efficacy of these agents in preventing delirium remains unclear.
OBJECTIVE: To compare and rank the efficacy of different pharmacological interventions for the prevention of delirium.
DESIGN: A systematic review and network meta-analysis.
METHODS: Relevant randomized controlled trials on drug prevention of delirium were extracted from three electronic databases. A network meta-analysis was then conducted to assess the relative efficacy of drug interventions in preventing delirium. The quality of the data was evaluated using the Cochrane Risk of Bias tool.
RESULTS: A total of 80 randomized controlled trials on drug interventions were included in the final analysis. Treatment with dexmedetomidine can prevent delirium.
CONCLUSION: Dexmedetomidine treatment can prevent delirium and reduce patient suffering. Healthcare professionals should be encouraged to use dexmedetomidine for delirium prevention.
OBJECTIVE: To compare and rank the efficacy of different pharmacological interventions for the prevention of delirium.
DESIGN: A systematic review and network meta-analysis.
METHODS: Relevant randomized controlled trials on drug prevention of delirium were extracted from three electronic databases. A network meta-analysis was then conducted to assess the relative efficacy of drug interventions in preventing delirium. The quality of the data was evaluated using the Cochrane Risk of Bias tool.
RESULTS: A total of 80 randomized controlled trials on drug interventions were included in the final analysis. Treatment with dexmedetomidine can prevent delirium.
CONCLUSION: Dexmedetomidine treatment can prevent delirium and reduce patient suffering. Healthcare professionals should be encouraged to use dexmedetomidine for delirium prevention.