The Burden of Acute Kidney Injury and Related Financial Issues.

BACKGROUND: Acute kidney injury (AKI) is one of the most common complications in acutely ill patients. The epidemiology, clinical presentation, and outcome vary between patients and countries.

SUMMARY: Patients with AKI often exhibit multiple organ dysfunction that is caused, in part, by marked cross-talk between the kidney and other organs and tissues. These deleterious interactions arise, at least in part, from systemic inflammatory changes, an increased cytokine load, increases in leukocyte trafficking and activation of neurohormonal processes. Typical short-term complications of AKI include acute lung injury, liver dysfunction, cardio-renal syndrome, brain dysfunction, systemic inflammation, and increased mortality. Survivors of AKI are at risk of chronic kidney disease, cardiovascular morbidity, strokes, infections, bone fractures and increased mortality. AKI is associated with high healthcare costs as a result of a longer stay in hospital, increased costs for investigations and interventions and the development of long-term complications including dialysis dependence, chronic comorbidities and re-hospitalisations. The outcomes and financial implications are worse in low-income countries compared to high-income countries. Key Message: AKI is common among hospitalised patients and associated with serious short- and long-term complications, increased mortality, and high health care costs. There are important differences in epidemiology and outcomes between low- and high-income countries.