Sultan Qaboos University medical journal · 2018
Determination of an Aspergillus fumigatus-Specific Immunoglobulin G Reference Range in an Adult Omani Population.
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Al-Rahman Munira, Al Kindi Mahmood, Kutty Ibrahim, Al-Kalbani Ibrahim, Alshekaili Jalila
Аннотация
OBJECTIVES: The presence of abnormally high levels of Aspergillus fumigatus-specific immunoglobulin (Ig) G antibodies can serve as a diagnostic criterion for severe conditions like allergic bronchopulmonary and chronic pulmonary aspergillosis. This study aimed to determine a reference range of A. fumigatus-specific IgG levels within a healthy adult Omani population.
METHODS: This study took place during November 2015 at the Sultan Qaboos University Hospital, Muscat, Oman. The sera of 125 healthy Omani blood donors were tested for A. fumigatus-specific IgG levels using an automated fluorescence enzyme immunoassay.
RESULTS: Initially, the data were not normally distributed; however, log transformation and the exclusion of four outliers resulted in an acceptable Gaussian distribution. The reference range was 2.0-68.7 mgA/L at the 2.5th and 97.5th percentiles, respectively, with 90% confidence intervals of 2.0-3.0 mgA/L and 48.0-76.0 mgA/L, respectively.
CONCLUSION: The A. fumigatus-specific IgG reference range within a healthy adult Omani population was comparable to those reported in other populations.
METHODS: This study took place during November 2015 at the Sultan Qaboos University Hospital, Muscat, Oman. The sera of 125 healthy Omani blood donors were tested for A. fumigatus-specific IgG levels using an automated fluorescence enzyme immunoassay.
RESULTS: Initially, the data were not normally distributed; however, log transformation and the exclusion of four outliers resulted in an acceptable Gaussian distribution. The reference range was 2.0-68.7 mgA/L at the 2.5th and 97.5th percentiles, respectively, with 90% confidence intervals of 2.0-3.0 mgA/L and 48.0-76.0 mgA/L, respectively.
CONCLUSION: The A. fumigatus-specific IgG reference range within a healthy adult Omani population was comparable to those reported in other populations.