European journal of obstetrics, gynecology, and reproductive biology · 2004
Performance of a novel test to quantify activated protein C resistance in women with a history of pre-eclampsia.
Оценочное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Nap Annemiek W, Hamulyak Karly, van Oerle Rene, van Pampus Lizzy C M, Spaanderman Marc E, Damoiseaux Jan, Rosing Jan, Peeters Louis L
Аннотация
OBJECTIVE: We determined the performance of a functional test for activated protein C (APC) resistance in formerly pre-eclamptic women and matched controls.
STUDY DESIGN: In our university medical center, we assessed the response to APC in plasma in 118 formerly pre-eclamptic women and in 57 healthy controls, we measured plasma levels of thrombophilic factors and we performed statistical analysis.
RESULTS: The incidence of APC resistance was significantly higher in formerly pre-eclamptics than in controls. Formerly APC resistant pre-eclamptics more often experienced intra-uterine growth restriction (IUGR) than their non-APC resistant counterparts.
CONCLUSION: APC resistance determined by this functional test is present in a large subgroup of formerly pre-eclamptics. A higher incidence of IUGR in this group suggests a more severe course of the experienced pregnancy complications. Additional study is needed to determine whether this test is sensitive in predicting recurrence of pre-eclampsia or IUGR.
STUDY DESIGN: In our university medical center, we assessed the response to APC in plasma in 118 formerly pre-eclamptic women and in 57 healthy controls, we measured plasma levels of thrombophilic factors and we performed statistical analysis.
RESULTS: The incidence of APC resistance was significantly higher in formerly pre-eclamptics than in controls. Formerly APC resistant pre-eclamptics more often experienced intra-uterine growth restriction (IUGR) than their non-APC resistant counterparts.
CONCLUSION: APC resistance determined by this functional test is present in a large subgroup of formerly pre-eclamptics. A higher incidence of IUGR in this group suggests a more severe course of the experienced pregnancy complications. Additional study is needed to determine whether this test is sensitive in predicting recurrence of pre-eclampsia or IUGR.