Journal of periodontology · 2012
Efficacy of using PDGF and xenograft with or without collagen membrane for bone regeneration around immediate implants with induced dehiscence-type defects: a microcomputed tomographic study in dogs.
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Al-Hazmi Bann Ahmad, Al-Hamdan Khalid Saleh, Al-Rasheed Abdulaziz, Babay Nadir, Wang Hom-Lay, Al-Hezaimi Khalid
Аннотация
BACKGROUND: Use of collagen membrane (CM) with xenograft and recombinant human platelet-derived growth factor (rhPDGF) in guided bone regeneration (GBR) is debatable. The aim of this microcomputed tomographic experiment was to assess the efficacy of using PDGF and xenograft (with or without CM) for GBR around immediate implants with dehiscence defects.
METHODS: Ten beagle dogs underwent atraumatic bilateral second and fourth premolar extractions from both arches. A standardized dehiscence defect (6 × 3 mm) was created on the buccal bone and immediate implants were placed in distal sockets in each site. Animals were randomly divided into three groups: 1) group 1, xenograft with rhPDGF was placed and covered with CM; 2) group 2, xenograft with rhPDGF was placed over the defects; and 3) group 3, four immediate implants were associated with dehiscence (controls). After 16 weeks, animals were sacrificed and jaw segments were assessed for buccal bone thickness (BBT), buccal bone volume (BBV), vertical bone height (VBH), and bone-to-implant contact (BIC) using microcomputed tomography.
RESULTS: BBT was higher in group 2 (1.533 ± 0.89 mm) than group 1 (0.745 ± 0.322 mm) (P <0.001) and group 3 (0.257 ± 0.232 mm) (P <0.05). BBV was higher in group 2 (67.87 ± 19.83 mm(3)) than group 1 (42.47 ± 6.78 mm(3)) (P <0.05) and group 3 (19.12 ± 4.06 mm(3)) (P <0.001). VBH was higher in group 2 (6.36 ± 1.37 mm) than group 3 (0.00 ± 0.00 mm) (P <0.001). VBH was higher in group 1 (3.91 ± 2.68 mm) than group 3 (0.00 ± 0.00 mm) (P <0.05). BIC was higher in group 2 (67.25% ± 13.42%) than group 1 (36.25% ± 12.78%) (P <0.05) and group 3 (30.25% ± 7.27%) (P <0.01).
CONCLUSION: GBR around immediate implants with dehiscence defects using PDGF and xenograft alone resulted in higher BBT, BBV, VBH, and BIC than when performed in combination with CM.
METHODS: Ten beagle dogs underwent atraumatic bilateral second and fourth premolar extractions from both arches. A standardized dehiscence defect (6 × 3 mm) was created on the buccal bone and immediate implants were placed in distal sockets in each site. Animals were randomly divided into three groups: 1) group 1, xenograft with rhPDGF was placed and covered with CM; 2) group 2, xenograft with rhPDGF was placed over the defects; and 3) group 3, four immediate implants were associated with dehiscence (controls). After 16 weeks, animals were sacrificed and jaw segments were assessed for buccal bone thickness (BBT), buccal bone volume (BBV), vertical bone height (VBH), and bone-to-implant contact (BIC) using microcomputed tomography.
RESULTS: BBT was higher in group 2 (1.533 ± 0.89 mm) than group 1 (0.745 ± 0.322 mm) (P <0.001) and group 3 (0.257 ± 0.232 mm) (P <0.05). BBV was higher in group 2 (67.87 ± 19.83 mm(3)) than group 1 (42.47 ± 6.78 mm(3)) (P <0.05) and group 3 (19.12 ± 4.06 mm(3)) (P <0.001). VBH was higher in group 2 (6.36 ± 1.37 mm) than group 3 (0.00 ± 0.00 mm) (P <0.001). VBH was higher in group 1 (3.91 ± 2.68 mm) than group 3 (0.00 ± 0.00 mm) (P <0.05). BIC was higher in group 2 (67.25% ± 13.42%) than group 1 (36.25% ± 12.78%) (P <0.05) and group 3 (30.25% ± 7.27%) (P <0.01).
CONCLUSION: GBR around immediate implants with dehiscence defects using PDGF and xenograft alone resulted in higher BBT, BBV, VBH, and BIC than when performed in combination with CM.
Предметные рубрики MeSH
Alveolar ProcessAnimalsBone RegenerationBone TransplantationCollagenDental Implantation, EndosseousDental ImplantsDogsFemaleGuided Tissue Regeneration, PeriodontalImplants, ExperimentalMembranesOsseointegrationPlatelet-Derived Growth FactorRandom AllocationRecombinant ProteinsSurgical Wound DehiscenceTooth SocketTransplantation, HeterologousX-Ray Microtomography