Hepatobiliary & pancreatic diseases international : HBPD INT · 2015
Splenic artery trunk embolization reduces the surgical risk of liver transplantation.
Clinical StudyСтатьяНазвание и аннотация: Перевод в очереди
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Li Yi-Ning, Miao Xiong-Ying, Qi Hai-Zhi, Hu Wei, Si Zhong-Zhou, Li Jie-Qun, Li Ting, He Zhi-Jun
Аннотация
BACKGROUND: Portal hypertension is one of the most important clinical conditions that cause intraoperative intensive hemorrhage in cirrhotic patients undergoing liver transplantation. Pre-transplant portal decompression may reduce the intraoperative bleeding during liver transplantation.
METHODS: Splenic artery trunk embolization (SATE) was performed one month prior to liver transplantation. Platelet count, prealbumin, international normalized ratio, and blood flow in the portal vein and hepatic artery were monitored before and one month after SATE. The measurements above were collected on admission and before surgery in the non-SATE patients, who served as controls. We also recorded the intraoperative blood loss, operating time, required transfusion, post-transplant ascites, and complications within three months after operation in all patients.
RESULTS: SATE significantly reduced portal venous blood flow, increased hepatic arterial blood flow, normalized platelet count, and improved prealbumin and international normalized ratio in the patients before liver transplantation. Compared to the non-SATE patients, the pre-transplant SATE significantly decreased the operating time, intraoperative bleeding, post-transplant ascites and severe surgical complications.
CONCLUSION: Pre-transplant SATE decreases portal pressure, improves liver function reserve, and reduces the surgical risk of liver transplantation effectively in patients with severe portal hypertension.
METHODS: Splenic artery trunk embolization (SATE) was performed one month prior to liver transplantation. Platelet count, prealbumin, international normalized ratio, and blood flow in the portal vein and hepatic artery were monitored before and one month after SATE. The measurements above were collected on admission and before surgery in the non-SATE patients, who served as controls. We also recorded the intraoperative blood loss, operating time, required transfusion, post-transplant ascites, and complications within three months after operation in all patients.
RESULTS: SATE significantly reduced portal venous blood flow, increased hepatic arterial blood flow, normalized platelet count, and improved prealbumin and international normalized ratio in the patients before liver transplantation. Compared to the non-SATE patients, the pre-transplant SATE significantly decreased the operating time, intraoperative bleeding, post-transplant ascites and severe surgical complications.
CONCLUSION: Pre-transplant SATE decreases portal pressure, improves liver function reserve, and reduces the surgical risk of liver transplantation effectively in patients with severe portal hypertension.
Предметные рубрики MeSH
AdultAscitesBiomarkersBlood CoagulationBlood Flow VelocityBlood Loss, SurgicalEmbolization, TherapeuticFemaleHepatic ArteryHumansHypertension, PortalInternational Normalized RatioLiver CirculationLiver TransplantationMaleMiddle AgedOperative TimePlatelet CountPortal PressurePortal VeinPrealbuminPreoperative CareRisk FactorsSeverity of Illness IndexSplenic ArteryTime FactorsTreatment Outcome