The Journal of clinical endocrinology and metabolism · 2025
Risk of Gestational Diabetes in Women With PCOS Based on Body Mass Index: The Japan Environment and Children's Study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Okoshi Chihiro, Kyozuka Hyo, Fukuda Toma, Yasuda Shun, Murata Tsuyoshi, Isogami Hirotaka, Sato Akiko, Ogata Yuka, Hosoya Mitsuaki, Yasumura Seiji, Hashimoto Koichi, Nishigori Hidekazu, Kamijima Michihiro, Yamazaki Shin, Ohya Yukihiro, Kishi Reiko, Yaegashi Nobuo, Mori Chisato, Ito Shuichi, Yamagata Zentaro, Inadera Hidekuni, Nakayama Takeo, Sobue Tomotaka, Shima Masayuki, Kageyama Seiji, Suganuma Narufumi, Ohga Shouichi, Katoh Takahiko, Fujimori Keiya, Takahashi Toshifumi
Аннотация
CONTEXT: Women with polycystic ovary syndrome (PCOS), which is the most common endocrine disorder in women of reproductive age, have a potentially increased risk of gestational diabetes mellitus (GDM).
OBJECTIVE: To examine the impact of PCOS on GDM based on maternal body mass index (BMI) using data from a large birth cohort study in Japan.
DESIGN: Prospective observational study using data from the Japan Environment and Children's Study (JECS).
PARTICIPANTS: Singleton pregnancies in the JECS during 2011-2014 were included. Mothers with HbA1c levels of ≥6.5% in the first trimester and history of diabetes mellitus or steroid use during pregnancy were excluded.
MAIN OUTCOME MEASURES: Participants were categorized according to their prepregnancy BMIs: G1 (<18.5 kg/m2), G2 (18.5-19.99 kg/m2), G3 (20.0-22.99 kg/m2), G4 (23.0-24.99 kg/m2), and G5 (≥25.0 kg/m2). The impact of PCOS on early(Ed) and late-onset(Ld) GDM for each group was estimated using a multiple logistic regression model.
RESULTS: We included 92 774 participants, comprising 2012 PCOS(+) cases. GDM occurrence was higher in women with PCOS (P < .001). PCOS had no effect on GDM in G1, G2, and G3. In G4, PCOS increased the risk of Ed GDM (adjusted odds ratio [aOR]: 3.27; 95% confidence interval [CI], 1.29-8.29). In G5, PCOS increased the risk of both Ed (aOR: 2.48; 95% CI, 1.53-4.02) and Ld GDM (aOR: 1.94; 95% CI, 1.23-3.07).
CONCLUSION: The impact of PCOS on GDM occurrence depended on the prepregnancy BMIs, which may facilitate personalized preconception counseling among women with PCOS.
OBJECTIVE: To examine the impact of PCOS on GDM based on maternal body mass index (BMI) using data from a large birth cohort study in Japan.
DESIGN: Prospective observational study using data from the Japan Environment and Children's Study (JECS).
PARTICIPANTS: Singleton pregnancies in the JECS during 2011-2014 were included. Mothers with HbA1c levels of ≥6.5% in the first trimester and history of diabetes mellitus or steroid use during pregnancy were excluded.
MAIN OUTCOME MEASURES: Participants were categorized according to their prepregnancy BMIs: G1 (<18.5 kg/m2), G2 (18.5-19.99 kg/m2), G3 (20.0-22.99 kg/m2), G4 (23.0-24.99 kg/m2), and G5 (≥25.0 kg/m2). The impact of PCOS on early(Ed) and late-onset(Ld) GDM for each group was estimated using a multiple logistic regression model.
RESULTS: We included 92 774 participants, comprising 2012 PCOS(+) cases. GDM occurrence was higher in women with PCOS (P < .001). PCOS had no effect on GDM in G1, G2, and G3. In G4, PCOS increased the risk of Ed GDM (adjusted odds ratio [aOR]: 3.27; 95% confidence interval [CI], 1.29-8.29). In G5, PCOS increased the risk of both Ed (aOR: 2.48; 95% CI, 1.53-4.02) and Ld GDM (aOR: 1.94; 95% CI, 1.23-3.07).
CONCLUSION: The impact of PCOS on GDM occurrence depended on the prepregnancy BMIs, which may facilitate personalized preconception counseling among women with PCOS.