Parasitology · 2013
Trypanosoma evansi infection impairs memory, increases anxiety behaviour and alters neurochemical parameters in rats.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Wolkmer Patrícia, Paim Francine C, DA Silva Cássia B, Gai Bibiana M, Carvalho Fabiano B, DA Souza Ana Cristina G, DA Rosa Michelle M, DA Silva Aleksandro S, Pereira Paula R, Lopes Sonia T A, Nogueira Cristina W, Rubin Maribel A, Monteiro Silvia G, Mazzanti Cinthia M
Аннотация
The aim of this study was to investigate neurochemical and enzymatic changes in rats infected with Trypanosoma evansi, and their interference in the cognitive parameters. Behavioural assessment (assessment of cognitive performance), evaluation of cerebral L-[3H]glutamate uptake, acetylcholinesterase (AChE) activity and Ca+2 and Na+, K+-ATPase activity were evaluated at 5 and 30 days post infection (dpi). This study demonstrates a cognitive impairment in rats infected with T. evansi. At 5 dpi memory deficit was demonstrated by an inhibitory avoidance test. With the chronicity of the disease (30 dpi) animals showed anxiety symptoms. It is possible the inhibition of cerebral Na+, K+-ATPase activity, AChE and synaptosomal glutamate uptake are involved in cognitive impairment in infected rats by T. evansi. The understanding of cerebral host–parasite relationship may shed some light on the cryptic symptoms of animals and possibly human infection where patients often present with other central nervous system (CNS) disorders.