South Asian journal of cancer · 2013
Chronic myeloid leukemia in children and adolescents: A single center experience from Eastern India.
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Raut Lalit, Bohara Vinay V, Ray Siddhartha S, Chakrabarti Prantar, Chaudhuri Utpal
Аннотация
CONTEXT: Chronic Myeloid Leukemia (CML) constitutes around 3% of leukemia in the children and adolescent age group.
AIMS: The aim of the study was to evaluate the characteristics at presentation and the treatment outcome of CML in the children and adolescent age group.
SETTINGS AND DESIGN: Retrospective analysis was carried out at a single center in India.
MATERIALS AND METHODS: Thirteen patients (≤17 years) attending CML outdoor from April 2008 to August 2012 were included in the analysis.
STATISTICAL ANALYSIS USED: The mean and median of various parameters were calculated using a Microsoft excel sheet. SPSS 16.0 version software was used to calculate OS and PFS.
RESULTS: CML-CP was the most common phase at presentation. Maximum patients belonged to the 14 - 17 year old age group. Disease was common in the male sex. Splenic discomfort and asthenia were the most common symptoms and splenomegaly was the most common sign.
CONCLUSIONS: The treatment with Imatinib was effective and well-tolerated.
AIMS: The aim of the study was to evaluate the characteristics at presentation and the treatment outcome of CML in the children and adolescent age group.
SETTINGS AND DESIGN: Retrospective analysis was carried out at a single center in India.
MATERIALS AND METHODS: Thirteen patients (≤17 years) attending CML outdoor from April 2008 to August 2012 were included in the analysis.
STATISTICAL ANALYSIS USED: The mean and median of various parameters were calculated using a Microsoft excel sheet. SPSS 16.0 version software was used to calculate OS and PFS.
RESULTS: CML-CP was the most common phase at presentation. Maximum patients belonged to the 14 - 17 year old age group. Disease was common in the male sex. Splenic discomfort and asthenia were the most common symptoms and splenomegaly was the most common sign.
CONCLUSIONS: The treatment with Imatinib was effective and well-tolerated.