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DOI 10.1016/j.cell.2022.12.027

Медицинская библиотека · Cell · 2023

Loss of epigenetic information as a cause of mammalian aging.

Yang Jae-Hyun, Hayano Motoshi, Griffin Patrick T, Amorim João A, Bonkowski Michael S, Apostolides John K, Salfati Elias L, Blanchette Marco, Munding Elizabeth M, Bhakta Mital, Chew Yap Ching, Guo Wei, Yang Xiaojing, Maybury-Lewis Sun, Tian Xiao, Ross Jaime M, Coppotelli Giuseppe, Meer Margarita V, Rogers-Hammond Ryan, Vera Daniel L, Lu Yuancheng Ryan, Pippin Jeffrey W, Creswell Michael L, Dou Zhixun, Xu Caiyue, Mitchell Sarah J, Das Abhirup, O'Connell Brendan L, Thakur Sachin, Kane Alice E, Su Qiao, Mohri Yasuaki, Nishimura Emi K, Schaevitz Laura, Garg Neha, Balta Ana-Maria, Rego Meghan A, Gregory-Ksander Meredith, Jakobs Tatjana C, Zhong Lei, Wakimoto Hiroko, El Andari Jihad, Grimm Dirk, Mostoslavsky Raul, Wagers Amy J, Tsubota Kazuo, Bonasera Stephen J, Palmeira Carlos M, Seidman Jonathan G, Seidman Christine E, Wolf Norman S, Kreiling Jill A, Sedivy John M, Murphy George F, Green Richard E, Garcia Benjamin A, Berger Shelley L, Oberdoerffer Philipp, Shankland Stuart J, Gladyshev Vadim N, Ksander Bruce R, Pfenning Andreas R, Rajman Luis A, Sinclair David A

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

All living things experience an increase in entropy, manifested as a loss of genetic and epigenetic information. In yeast, epigenetic information is lost over time due to the relocalization of chromatin-modifying proteins to DNA breaks, causing cells to lose their identity, a hallmark of yeast aging. Using a system called "ICE" (inducible changes to the epigenome), we find that the act of faithful DNA repair advances aging at physiological, cognitive, and molecular levels, including erosion of the epigenetic landscape, cellular exdifferentiation, senescence, and advancement of the DNA methylation clock, which can be reversed by OSK-mediated rejuvenation. These data are consistent with the information theory of aging, which states that a loss of epigenetic information is a reversible cause of aging.

Для цитирования: Yang Jae-Hyun, Hayano Motoshi, Griffin Patrick T, Amorim João A, Bonkowski Michael S, Apostolides John K, Salfati Elias L, Blanchette Marco, Munding Elizabeth M, Bhakta Mital, Chew Yap Ching, Guo Wei, Yang Xiaojing, Maybury-Lewis Sun, Tian Xiao, Ross Jaime M, Coppotelli Giuseppe, Meer Margarita V, Rogers-Hammond Ryan, Vera Daniel L, Lu Yuancheng Ryan, Pippin Jeffrey W, Creswell Michael L, Dou Zhixun, Xu Caiyue, Mitchell Sarah J, Das Abhirup, O'Connell Brendan L, Thakur Sachin, Kane Alice E, Su Qiao, Mohri Yasuaki, Nishimura Emi K, Schaevitz Laura, Garg Neha, Balta Ana-Maria, Rego Meghan A, Gregory-Ksander Meredith, Jakobs Tatjana C, Zhong Lei, Wakimoto Hiroko, El Andari Jihad, Grimm Dirk, Mostoslavsky Raul, Wagers Amy J, Tsubota Kazuo, Bonasera Stephen J, Palmeira Carlos M, Seidman Jonathan G, Seidman Christine E, Wolf Norman S, Kreiling Jill A, Sedivy John M, Murphy George F, Green Richard E, Garcia Benjamin A, Berger Shelley L, Oberdoerffer Philipp, Shankland Stuart J, Gladyshev Vadim N, Ksander Bruce R, Pfenning Andreas R, Rajman Luis A, Sinclair David A. Loss of epigenetic information as a cause of mammalian aging.. Cell. 2023. DOI: 10.1016/j.cell.2022.12.027.

Предметные рубрики MeSH

AnimalsAgingDNA MethylationEpigenesis, GeneticEpigenomeMammalsNucleoproteinsSaccharomyces cerevisiae
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