British journal of anaesthesia · 2005
Effect of neurolytic nerve block on systemic carrageenan-induced inflammatory response in mice.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Pham-Marcou T A, Gentili M, Asehnoune K, Fletcher D, Mazoit J-X
Аннотация
BACKGROUND: Local tissue inflammation caused by injury or inflammatory processes may be reduced by section or local anaesthetic block of the nerve innervating the inflamed area.
METHODS: Using a neurolytic nerve block, we assessed the systemic inflammatory response elicited by a local injection of carrageenan in mice. Sixty mice received a unilateral sciatic nerve block with 70% ethanol followed 5 days later by an injection of carrageenan on the ipsilateral or contralateral hind paw. Whole blood was sampled 15 h after carrageenan injection.
RESULTS: Fifty-six animals had a complete nerve block. Tumour necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta) and interleukin 10 (IL-10) concentrations were measured in the plasma of 20 mice (10 in the ispilateral group and 10 in the contralateral group). In the remaining 36 mice (18 in each group), blood was cultured for 24 h in the presence of lipopolysaccharide or Staphylococcus aureus extract. TNF-alpha and IL-1beta production in the supernatant were, on average, 30% lower in the ispilateral group than in the contralateral group.
CONCLUSION: A prolonged nerve block decreases the systemic consequences of the local inflammatory reaction elicited by carrageenan injection.
METHODS: Using a neurolytic nerve block, we assessed the systemic inflammatory response elicited by a local injection of carrageenan in mice. Sixty mice received a unilateral sciatic nerve block with 70% ethanol followed 5 days later by an injection of carrageenan on the ipsilateral or contralateral hind paw. Whole blood was sampled 15 h after carrageenan injection.
RESULTS: Fifty-six animals had a complete nerve block. Tumour necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta) and interleukin 10 (IL-10) concentrations were measured in the plasma of 20 mice (10 in the ispilateral group and 10 in the contralateral group). In the remaining 36 mice (18 in each group), blood was cultured for 24 h in the presence of lipopolysaccharide or Staphylococcus aureus extract. TNF-alpha and IL-1beta production in the supernatant were, on average, 30% lower in the ispilateral group than in the contralateral group.
CONCLUSION: A prolonged nerve block decreases the systemic consequences of the local inflammatory reaction elicited by carrageenan injection.