Cibenzoline intoxication: effect of combined hemoperfusion-hemodialysis on plasma clearance.

INTRODUCTION

Cibenzoline is an antiarrhythmic drug used to treat patients with supraventricular or ventricular arrhythmias. Cibenzoline overdose is associated with proarrhythmic and hemodynamic effects such as hypotension and congestive heart failure.

CASE REPORT: We report a case of cardiogenic shock due to cibenzoline overdose in a patient with progressive renal insufficiency.

DISCUSSION: The standard treatment of a cibenzoline intoxication is symptomatic, but we used combined hemoperfusion-hemodialysis to treat our patient.

CONCLUSIONS

This was associated with a rapid decline in plasma cibenzoline concentration and improvement of the clinical condition. However, only 28.98 mg of an estimated body pool of cibenzoline (447.2 to 806.6 mg) was removed during the 8 hours of treatment.