The analytical prognosis of the susceptibility to aminoglycosides and doxycycline inacinetobacter baumanniiisoolated from burns of intensive care unit patients.

OBJECTIVE

Introduction

Clinical strains of A.baumannii are becoming highly important in hospital-acquired infections, especially because of their association with low susceptibility to antibiotics, which requires in-depth study with a prognostic determination of the dynamics of antimicrobial efficacy of antibiotics. The aim was to investigate of prognostic models of aminoglycoside antibiotics effectiveness on the basis of the mathematical analysis of real susceptibility of A.baumannii clinical strains, isolated from patients in BICU.

PATIENTS AND

METHODS

Materials and methods: In the research there were enrolled 435 patients who had undergone treatment of the 2ndb - 3rd degree burns at the burn department of the Vinnitsa Regional Clinical Hospital N. I. Pirogov during 2011-2016. In total, 222 clinical strains of A.baumannii were isolated in early period after burn trauma before antibiotic therapy. The susceptibility of clinical strains A.baumannii to the gentamicin, tobramycin, amikacin, doxycycline was defined by qualitative disco-diffusion and quantitative double dilution methods.

RESULTS

Results

The results of the study demonstrated a low susceptibility of clinical strains of A.baumannii to the studied aminoglicosides and doxycycline. During 2011-2016 the highest sensitivity of Acinetobacter to gentamicin (65%), tobramycin (68,63%) was estimated in 2015. But determined in 2016-2017 following tendency of susceptibility criteria of Acinetobactergave the possibility to found prognostic decreasing of gentamicin and tobramycin efficacy against this pathogen (less than 50%) in critically ill with burns.

CONCLUSION

Conclusion

A.baumannii, pathogens of infectious complications in patiens, were characterized by a decrease in sensitivity to gentamycin, tobramycin and amikacin. Despite of low efficacy rate of doxycycline the recovery of its effectiveness against A.baumannii is excepted.