The Journal of urology · 1999
Histopathology and molecular genetics of renal tumors toward unification of a classification system.
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Zambrano N R, Lubensky I A, Merino M J, Linehan W M, Walther M M
Аннотация
PURPOSE: We characterize the genetic abnormalities associated with pathological subtypes of renal tumors, which may help diagnosis or prognostication.
MATERIALS AND METHODS: A comprehensive literature review of genetic abnormalities associated with different renal tumor subtypes was performed.
RESULTS: Studies of sporadic and hereditary forms suggest that abnormalities in the von Hippel-Lindau and met genes are the earliest changes in conventional (clear cell) and papillary basophilic renal cancers, respectively. Renal oncocytoma and chromophobe carcinoma have common genetic abnormalities, suggesting a relationship. A similar finding has been observed between papillary adenoma and papillary basophilic renal cancer.
CONCLUSIONS: These findings suggest that molecular diagnostic testing will help determine histopathological diagnosis, identify tumor types with similar genetic abnormalities suggesting a common origin and indicate potential prognostic markers for future study.
MATERIALS AND METHODS: A comprehensive literature review of genetic abnormalities associated with different renal tumor subtypes was performed.
RESULTS: Studies of sporadic and hereditary forms suggest that abnormalities in the von Hippel-Lindau and met genes are the earliest changes in conventional (clear cell) and papillary basophilic renal cancers, respectively. Renal oncocytoma and chromophobe carcinoma have common genetic abnormalities, suggesting a relationship. A similar finding has been observed between papillary adenoma and papillary basophilic renal cancer.
CONCLUSIONS: These findings suggest that molecular diagnostic testing will help determine histopathological diagnosis, identify tumor types with similar genetic abnormalities suggesting a common origin and indicate potential prognostic markers for future study.